Anticancer potential of phytochemicals derived from mangrove plants: Comprehensive mechanistic insights

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dc.authoridSharifi-Rad, Javad/0000-0002-7301-8151
dc.authoridBhuia, Md. Shimul/0000-0002-6179-9720
dc.contributor.authorChowdhury, Raihan
dc.contributor.authorBhuia, Md. Shimul
dc.contributor.authorAl Hasan, Md. Sakib
dc.contributor.authorHossain Snigdha, Shadid
dc.contributor.authorAfrin, Sadia
dc.contributor.authorBusselberg, Dietrich
dc.contributor.authorHabtemariam, Solomon
dc.date.accessioned2024-10-26T18:11:30Z
dc.date.available2024-10-26T18:11:30Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractCancer is a collection of illnesses characterized by aberrant cellular proliferation that can infiltrate or metastasize to distant anatomical sites, posing a notable threat to human well-being due to its substantial morbidity and death rates worldwide. The potential of plant-derived natural compounds as anticancer medicines has been assessed owing to their favorable attributes of few side effects and significant antitumor activity. Mangrove plants and their derived compounds have been scientifically shown to exhibit many significant beneficial biological activities, such as anti-inflammatory, immunomodulatory, antioxidant, neuroprotective, cardioprotective, and hepatoprotective properties. This study summarized mangrove plants and their derived compounds as potential anticancer agents, with an emphasis on the underlying molecular mechanisms. To explore this, we gathered data on the preclinical (in vivo and in vitro) anticancer effects of mangrove plants and their derived compounds from reputable literature spanning 2000 to 2023. We conducted thorough searches in various academic databases, including PubMed, ScienceDirect, Wiley Online, SpringerLink, Google Scholar, Scopus, and the Web of Science. The results demonstrated that mangrove plants and their derived compounds have promising anticancer properties in preclinical pharmacological test systems through various molecular mechanisms, including induction of oxidative stress and mitochondrial dysfunction, cytotoxicity, genotoxicity, cell cycle arrest, apoptosis, autophagy, antiproliferative, antimetastatic, and other miscellaneous actions. Upon thorough observation of the pertinent information, it is suggested that mangrove plants and their derived chemicals may serve as a potential lead in the development of novel drugs for cancer therapy. The primary goal of the present study was to evaluate the anticancer abilities of mangrove plants and their compounds in great detail. In addition, we seek to investigate the molecular processes that give rise to mangrove plants and their phytochemical anticancer properties, focusing on their possible application in cancer treatment, which could provide valuable insights for future investigations and the development of novel therapeutic approaches.image
dc.description.sponsorshipThe authors have nothing to report.
dc.identifier.doi10.1002/fsn3.4318
dc.identifier.issn2048-7177
dc.identifier.scopus2-s2.0-85198092209
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1002/fsn3.4318
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30694
dc.identifier.wosWOS:001268184700001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofFood Science & Nutrition
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectanticancer phytochemicals
dc.subjectcancer
dc.subjectmangrove plants
dc.subjectmolecular mechanisms
dc.titleAnticancer potential of phytochemicals derived from mangrove plants: Comprehensive mechanistic insights
dc.typeReview Article

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