Homoharringtonine: updated insights into its efficacy in hematological malignancies, diverse cancers and other biomedical applications

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dc.authoridSharifi-Rad, Javad/0000-0002-7301-8151
dc.contributor.authorKhatua, Somanjana
dc.contributor.authorNandi, Sudeshna
dc.contributor.authorNag, Anish
dc.contributor.authorSen, Surjit
dc.contributor.authorChakraborty, Nilanjan
dc.contributor.authorNaskar, Arghya
dc.contributor.authorGurer, Eda Sonmez
dc.date.accessioned2024-10-26T18:11:22Z
dc.date.available2024-10-26T18:11:22Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractHHT has emerged as a notable compound in the realm of cancer treatment, particularly for hematological malignancies. Its multifaceted pharmacological properties extend beyond traditional applications, warranting an extensive review of its mechanisms and efficacy. This review aims to synthesize comprehensive insights into the efficacy of HHT in treating hematological malignancies, diverse cancers, and other biomedical applications. It focuses on elucidating the molecular mechanisms, therapeutic potential, and broader applications of HHT. A comprehensive search for peer-reviewed papers was conducted across various academic databases, including ScienceDirect, Web of Science, Scopus, American Chemical Society, Google Scholar, PubMed/MedLine, and Wiley. The review highlights HHT's diverse mechanisms of action, ranging from its role in leukemia treatment to its emerging applications in managing other cancers and various biomedical conditions. It underscores HHT's influence on cellular processes, its efficacy in clinical settings, and its potential to alter pathological pathways. HHT demonstrates significant promise in treating various hematological malignancies and cancers, offering a multifaceted approach to disease management. Its ability to impact various physiological pathways opens new avenues for therapeutic applications. This review provides a consolidated foundation for future research and clinical applications of HHT in diverse medical fields.
dc.description.sponsorshipBasildon University Hospital UK
dc.description.sponsorshipThe authors would like to express their gratitude to Dr. Irina Zamfir, RCP London, Basildon University Hospital UK, for providing professional English editing of this manuscript and for editorial support.
dc.identifier.doi10.1186/s40001-024-01856-x
dc.identifier.issn0949-2321
dc.identifier.issn2047-783X
dc.identifier.issue1
dc.identifier.pmid38704602
dc.identifier.scopus2-s2.0-85192319548
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1186/s40001-024-01856-x
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30642
dc.identifier.volume29
dc.identifier.wosWOS:001214183700002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBmc
dc.relation.ispartofEuropean Journal of Medical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHomoharringtonine
dc.subjectLeukemia treatment
dc.subjectMolecular mechanisms
dc.subjectHematological malignancies
dc.subjectPharmacological efficacy
dc.subjectCancer therapeutics
dc.titleHomoharringtonine: updated insights into its efficacy in hematological malignancies, diverse cancers and other biomedical applications
dc.typeReview Article

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