Nimodipine can improve cerebral metabolism and outcome in patients with severe head trauma

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dc.contributor.authorAslan, Adem
dc.contributor.authorGurelik, Mustafa
dc.contributor.authorCemek, Mustafa
dc.contributor.authorGoksel, Hakan Murat
dc.contributor.authorBuyukokuroglu, Mehmet Emin
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:14:33Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:14:33Z
dc.date.issued2009
dc.department[Aslan, Adem] Afyon Kocatepe Univ, Fac Med, Dept Neurosurg, TR-03200 Afyon, Turkey -- [Gurelik, Mustafa -- Goksel, Hakan Murat] Cumhuriyet Univ, Fac Med, Dept Neurosurg, Sivas, Turkey -- [Cemek, Mustafa] Afyon Kocatepe Univ, Fac Sci & Arts, Dept Chem, Div Biochem, TR-03200 Afyon, Turkey -- [Buyukokuroglu, Mehmet Emin] Afyon Kocatepe Univ, Fac Med, Dept Pharmacol, TR-03200 Afyon, Turkeyen_US
dc.description.abstractIn the present study, the effect of nimodipine was investigated in a patient with severe head trauma. Nimodipine was administered into the peripheral vein to prevent secondary neuronal damages in patients. The five patients in control group were treated according to the standard procedures without nimodipine. Other five patients in nimodipine group were treated with standard procedures plus nimodipine. Cerebral perfusion pressure (CPP), intracranial pressure (ICP), jugular venous oxygen saturation (SjvO(2)), jugular lactate and glucose levels were measured. Additionally, all patients were evaluated with Glascow outcome score (GOS) before discharge. It was found that CPP (p < 0.05) and SjvO(2) (p < 0.05)were significantly higher; but, ICP (p < 0.001),jugular lactate (p < 0.05) and jugular glucose (p < 0.05) were lower in nimodipine than that of control groups. Again, GOS values were significantly higher in nimodipine than that of control groups (p < 0.05). Results of this study revealed that nimodipine can improve cerebral metabolism and outcome in patient with severe head trauma. Thus, nimodipine may be considered as a protective agent against severe head trauma related neuronal injuries. (C) 2008 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.phrs.2008.10.003en_US
dc.identifier.endpage124en_US
dc.identifier.issn1043-6618
dc.identifier.issue2en_US
dc.identifier.pmid18996202en_US
dc.identifier.scopus2-s2.0-58749098750en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage120en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.phrs.2008.10.003
dc.identifier.urihttps://hdl.handle.net/20.500.12418/10204
dc.identifier.volume59en_US
dc.identifier.wosWOS:000263708800006en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherACADEMIC PRESS LTD ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofPHARMACOLOGICAL RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNimodipineen_US
dc.subjectCerebral metabolismen_US
dc.subjectOutcomeen_US
dc.subjectSevere head traumaen_US
dc.titleNimodipine can improve cerebral metabolism and outcome in patients with severe head traumaen_US
dc.typeArticleen_US

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