The synthesis and anti-cancer efficacy of endoperoxide modified copper sulfide-ferritin nanocages as PDT and PTT agents

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dc.authoridSozmen, Fazli/0000-0002-2780-1487
dc.authoridULUSOY, SAKINE/0000-0001-9044-9079
dc.contributor.authorKucukoflaz, Merve
dc.contributor.authorUlusoy, Sakine
dc.contributor.authorKorkmaz, Bekir
dc.contributor.authorOzturk, Suleyman Can
dc.contributor.authorAkyol, Melih
dc.contributor.authorHayta, Sibel Berksoy
dc.contributor.authorGoze, Omer Fahrettin
dc.date.accessioned2024-10-26T18:07:25Z
dc.date.available2024-10-26T18:07:25Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractPhotodynamic therapy (PDT) using endoperoxides is to produce toxic singlet oxygen of reactive oxygen species through heat from the endoperoxides present in the medium. Compared with conventional PDT, PDT using endoperoxides has some advantages, for instance, in the presence of endoperoxide, singlet oxygen efficiency is not affected by hypoxic environment, because endoperoxides are the source of singlet oxygen. On the other hand, the kinetic stabilities of endoperoxides are important in the body temperature. Another advantage of endoperoxides is that they can produce singlet oxygen upon warming, so regardless of the wavelength of the emitted light, they can selectively produce singlet oxygen in the heated region. The aim of this study is to synthesize core-shell nanocages (10-Aft-CuS) with the synergistic effect of both photothermal therapy (PTT) and PDT by functionalizing the surface of the Apoferritin (Aft) nanocage platform with an endoperoxide derivative and forming ultra-small CuS nanoparticles in its inner cavity for the first time. So, first of all, Aft-CuS nanoparticles were obtained by the synthesis of ultra-small CuS nanoparticles in the inner cavity of Aft nanocages. Then, the surfaces of these nanocages have been functionalized with the Compound 10, an endoperoxide anthracene derivative. While the synthesized nanoparticles in this way have the synergistic effects of PTT and PDT therapies, achieving this with a natural nanoparticle has also been tested in cell cultures in vitro and in mice with progressed melanoma in vivo by increasing the effectiveness against cancer cells. 10-Aft-CuS nanocages showed high anti-tumor efficacy against malignant melanoma in vitro and in vivo.
dc.description.sponsorshipTUBITAK; [217Z027]
dc.description.sponsorshipThe authors gratefully acknowledge support from TUBITAK (Grant No. 217Z027
dc.identifier.doi10.1007/s11051-023-05719-0
dc.identifier.issn1388-0764
dc.identifier.issn1572-896X
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85150877097
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s11051-023-05719-0
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29471
dc.identifier.volume25
dc.identifier.wosWOS:000959565500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal of Nanoparticle Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFerritin nanoparticles
dc.subjectCuS nanoparticles
dc.subjectPhotodynamic therapy
dc.subjectPhotothermal therapy
dc.subjectMalignant melanoma
dc.subjectNanomedicine
dc.titleThe synthesis and anti-cancer efficacy of endoperoxide modified copper sulfide-ferritin nanocages as PDT and PTT agents
dc.typeArticle

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