Effect of silibinin on the hyperlipidemia in rats fed with high cholesterol diet

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dc.authoridduman, dildar/0000-0001-8680-8550
dc.contributor.authorDuman, Didem
dc.contributor.authorArpaci, Abdullah
dc.contributor.authorDirican, Emre
dc.contributor.authorBozdogan, Server
dc.contributor.authorBayraktar, Hamdullah Suphi
dc.date.accessioned2024-10-26T18:00:17Z
dc.date.available2024-10-26T18:00:17Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractPurpose: Despite current hypolipidemic drugs, the search for a more effective hypolipidemic agent is ongoing. In this study, it was aimed to investigate the effect of Silibinin on hyperlipidemia in rats fed high cholesterol diet (HCD). Materials and Methods: Rats were made obese. Rats were given egg yolk for 60 days and then 50 mg/kg, 100 mg/kg Silibinin were applied i.p. for 7 days. Results: The first and last weights of the rats were significantly different. While total cholesterol (TC), LDL, TG and VLDL levels increased significantly in the groups fed with HCD, HDL level reduced compared to control group (CG). OxLDL and TAS were significantly different between groups. Conclusion: The effects of Silibinin on serum LDL, TC, VLDL, HDL, TG, OxLDL levels and to observe the antioxidant effect, TAS and TOS were investigated in experimental obese rat models. It was concluded that Silibinin plays an effective role in lowering TG and LDL levels, increasing HDL levels and decreasing hepatic lipid accumulation in HCD rats at 100 mg/kg dose. The use of Silibinin does not cause antihyperlipidemic effect but has antioxidant effect.
dc.description.sponsorshipHatay Mustafa Kemal University [18.YL.023]
dc.description.sponsorshipThis study was supported by Hatay Mustafa Kemal University, Coordinatorship of Scientific Research Projects. Project no: 18.YL.023
dc.identifier.doi10.17826/cumj.788377
dc.identifier.endpage131
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.issue1
dc.identifier.startpage125
dc.identifier.trdizinid429338
dc.identifier.urihttps://doi.org/10.17826/cumj.788377
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/429338
dc.identifier.urihttps://hdl.handle.net/20.500.12418/27619
dc.identifier.volume46
dc.identifier.wosWOS:000632797000015
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherCukurova Univ, Fac Medicine
dc.relation.ispartofCukurova Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectSilibinin
dc.subjecthyperlipidemia
dc.subjectantioxidant
dc.subjectatherosclerosis
dc.titleEffect of silibinin on the hyperlipidemia in rats fed with high cholesterol diet
dc.typeArticle

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