Diagnostic value of C-reactive protein and soluble urokinase plasminogen activator receptor in canine monocytic ehrlichiosis

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dc.authoridERDOGAN, HASAN/0000-0001-5141-5108
dc.contributor.authorErdogan, Songul
dc.contributor.authorBasbug, Onur
dc.contributor.authorAydogdu, Ugur
dc.contributor.authorPasa, Serdar
dc.contributor.authorErdogan, Hasan
dc.contributor.authorUral, Kerem
dc.date.accessioned2024-10-26T18:09:25Z
dc.date.available2024-10-26T18:09:25Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractCanine monocytic ehrlichiosis is a vector-borne disease that can induce renal failure in dogs. In this study we aimed to describe the potential diagnostic efficiency of CRP and suPAR in dogs infected with E. canis and the association between suPAR and CRP with renal failure. For this purpose, the study consisted of a total of 17 dogs, 8 of infected with E. canis and 9 of healty. For evaluating renal failure, plasma urea-creatinine and UPC were determined and also measurements of plasma CRP and suPAR were analysed with ELISA test kits. Mean CRP, suPAR, urea, creatinine and UPC levels of the infected dogs were significantly higher compared with healthy ones (P 0.01) but the correlation of all parameters with each group was not significant (P 0.05). As to be a result of ROC curve analysis and Youdens index, the cut-off values for diagnosis of ehrlichiosis were identified to be 9.68 mg/L for CRP and 168.2 ng/L for suPAR. Furthermore, the specificity and sensitivity of both markers according as a potential biomarkers cut-off values were determined higher. In conclusion, traditionally CRP and currently suPAR can be considered as potential biomarkers and have a diagnostic significance following inflammation in canine ehrlichiosis.
dc.identifier.doi10.14456/tjvm.2021.68
dc.identifier.endpage575
dc.identifier.issn0125-6491
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85114434993
dc.identifier.scopusqualityQ3
dc.identifier.startpage567
dc.identifier.urihttps://doi.org/10.14456/tjvm.2021.68
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30092
dc.identifier.volume51
dc.identifier.wosWOS:000696995700014
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherChulalongkorn Univ
dc.relation.ispartofThai Journal of Veterinary Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCRP
dc.subjectsuPAR
dc.subjectkidney failure
dc.subjectinflammation
dc.subjectE
dc.subjectcanis
dc.titleDiagnostic value of C-reactive protein and soluble urokinase plasminogen activator receptor in canine monocytic ehrlichiosis
dc.typeArticle

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