Biological effects and molecular docking studies of Catechin 5-O-gallate: antioxidant, anticholinergics, antiepileptic and antidiabetic potentials

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dc.authoridhttps://orcid.org/0000-0002-0420-2043tr
dc.contributor.authorTaslimi, Parham
dc.contributor.authorKocyigit, Umit M.
dc.contributor.authorTüzün,Burak
dc.contributor.authorKirici, Mahinur
dc.date.accessioned2023-04-12T05:36:53Z
dc.date.available2023-04-12T05:36:53Z
dc.date.issued04.10.2020tr
dc.departmentSivas Meslek Yüksekokulutr
dc.description.abstractGallocatechin gallate is a form of catechin and an ester of gallocatechin and gallic acid. This is an epimer of the gallate epigallocatechin. In this study, the effect of this molecule, containing a biologically active group, was investigated in terms of important metabolic enzymes (carbonic anhydrase isoenzymes I and II (hCA I and II), achethylcholinesterase (AChE) and a-glycosidase (a-Gly) enzymes). The molecular docking method used to compare the biological activities of the Catechin 5-O-gallate molecule against enzymes was used. Afterwards, the ADME/T analysis was performed to investigate the drug availability of the Catechin 5-O-gallate molecule and the parameters obtained from ADME/T analysis were examined. Continuation of this study, for evaluating antioxidant and radical scavenging capacity Catechin 5-O-gallate, cupric ion (Cu2þ) reduction capacity by CUPRAC method, Fe3þ-Fe2þ reducing capacity, DPPH free radical clarifying (DPPH· ), ABTS radical clarifying (ABTS þ) were performed separately and during the study, trolox, a-tocopherol BHT and BHA were used as the reference antioxidant compound. Comparisons were applied with the four standard substances. Abbreviations: ADME: absorption, distribution, metabolism and excretion; ACR: acarbose; AZA: acetazolamide; AChE: achethylcholinesterase; ABTS: 2, 2’-azino-Bis-3-ethylbenzothiazoline-6-sulfonic acid (biochemical reagent); a-Gly: a-glycosidase; BHA: butylated hydroxyanisole; BHT: butylated hydroxytoluene; BChE: butyrylcholinesterase; CA: carbonic anhydrase; CUPRAC: cupric reducing antioxidant capacity; DPPH: 2,2-diphenyl-1-picrylhydrazyl; EGCG: gallate epigallocatechin; GA: gallic acid; GCG: gallocatechin gallatetr
dc.identifier.citationParham Taslimi, Umit M. Kocyigit, Burak Tüzün & Mahinur Kirici To cite this article: Parham Taslimi, Umit M. Kocyigit, Burak Tüzün & Mahinur Kirici (2022) Biological effects and molecular docking studies of Catechin 5-O-gallate: antioxidant, anticholinergics, antiepileptic and antidiabetic potentials, Journal of Biomolecular Structure andtr
dc.identifier.doi10.1080/07391102.2020.1840440en_US
dc.identifier.endpage2497tr
dc.identifier.issue6tr
dc.identifier.pmid33146092en_US
dc.identifier.scopus2-s2.0-85095731468en_US
dc.identifier.scopusqualityN/A
dc.identifier.startpage2489tr
dc.identifier.urihttps://hdl.handle.net/20.500.12418/13578
dc.identifier.volume40tr
dc.identifier.wosWOS:000584731700001en_US
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJournal of Biomolecular Structure and Dynamicstr
dc.relation.publicationcategoryUluslararası Editör Denetimli Dergide Makaletr
dc.rightsinfo:eu-repo/semantics/openAccesstr
dc.subjectCarbonic anhydrasetr
dc.subjectacetylcholinesterasetr
dc.subjecta-glycosidasetr
dc.subjectantioxidant activitytr
dc.subjectCatechin 5-O-gallatetr
dc.titleBiological effects and molecular docking studies of Catechin 5-O-gallate: antioxidant, anticholinergics, antiepileptic and antidiabetic potentialsen_US
dc.typeArticleen_US

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