Investigation of the effect of REM sleep deprivation on epileptic seizures caused by pentylenetetrazole in mice

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dc.contributor.authorAkkaya, Recep
dc.contributor.authorKarabulut, Sebahattin
dc.contributor.authorTaşkıran, Ahmet Şevki
dc.date.accessioned2024-10-26T17:41:07Z
dc.date.available2024-10-26T17:41:07Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractAim: To investigate whether different periods of rapid eye movement sleep deprivation (REM SD)contribute to seizure susceptibility, hippocampal oxidative status and balance of inhibition-excitationin the acute epilepsy model.Methods: REM SD was performed using the modified multiple platforms method on adult maleBALB/c mice. Pentylentetrazol (PTZ) was injected to induce seizures and hippocampal totalantioxidant status (TAS), total oxidant status (TOS), gamma aminobutyric acid (GABA), andglutamate levels were measured using the ELISA method.Results: PTZ-induced seizures following 8 h and 72 h REM SD significantly reduced thehippocampal TAS levels, but did not affect the TOS levels. In REM SD groups, especially after 8hours of REM sleep loss, there was a significant increase in glutamate in PTZ induction. Thehippocampal GABA levels were increased by PTZ-induced seizures after 72 h REM SD. PTZinduction after 8 hours of RAM SD leads to a significant increase in the seizure duration.Conclusion: It can be speculated that the REM SD can contribute to seizure susceptibility bychanging the oxidant-antioxidant balance and excitatory and inhibitory tone in the hippocampus.
dc.identifier.doi10.30714/j-ebr.2020361050
dc.identifier.endpage156
dc.identifier.issn2618-6454
dc.identifier.issue3
dc.identifier.startpage149
dc.identifier.trdizinid383979
dc.identifier.urihttps://doi.org/10.30714/j-ebr.2020361050
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/383979
dc.identifier.urihttps://hdl.handle.net/20.500.12418/24300
dc.identifier.volume3
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofExperimental Biomedical Research
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleInvestigation of the effect of REM sleep deprivation on epileptic seizures caused by pentylenetetrazole in mice
dc.typeArticle

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