Utilizing cell population data for diagnosis and intensive care unit requirement prediction in Fournier gangrene patients

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dc.authoridOzturk, Abuzer/0000-0002-6090-6133
dc.authoridERGIN, Ismail Emre/0000-0002-3115-0533
dc.authoridDOGAN, Halef Okan/0000-0001-8738-0760
dc.authoridKorgali, Esat/0000-0003-0318-0353
dc.authoridbolat, serkan/0000-0002-8669-8782
dc.contributor.authorSaygin, Hueseyin
dc.contributor.authorBolat, Serkan
dc.contributor.authorAsdemir, Aydemir
dc.contributor.authorOzturk, Abuzer
dc.contributor.authorErgin, Ismail E.
dc.contributor.authorDogan, Halef O.
dc.contributor.authorKorgali, Esat
dc.date.accessioned2024-10-26T18:07:37Z
dc.date.available2024-10-26T18:07:37Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjectives: It is vital to rapid diagnosis and to determine the intensive care unit (ICU) requirement early to reduce the mortality rate in Fournier gangrene (FG) patients. Cell population data (CPD) are the parameters obtained from complete blood count (CBC) analysis and related to the activation of different leukocyte subgroups. The study aimed to find reliable markers to diagnose and determine the ICU requirement using CPD. Methods: We included 24 patients and 22 healthy controls in the study. CBC analyses were performed by using a Sysmex XN-9000 series hematology analyzer. ROC analyses and group comparisons were performed to evaluate the diagnostic accuracy and prognostic value of CPD parameters in ICU requirements. Results: Statistically significant differences were observed in terms of some CPD values of lymphocytes, neutrophils, and monocytes in patients compared to healthy controls. Neutrophile-Y or reactivity index (Ne-Y or RI) (p=0.004), neutrophile-X or granularity index (Ne-X or GI) (p=0.009), monocyte-X (Mo-X) (p<0.001), and lymphocyte-WY (Ly-WY) (p<0.001) were higher in patients than controls. Ne-Y (RI) (p=0.012), Mo-X (p=0.001), Mo-Y (p=0.022), and Ne-WY (p=0.025) levels were higher in ICU patients than in non-ICU patients. Conclusions: The severity of FG disease can be determined using CPD data. Ne-Y (RI) serves as a novel and reliable biomarker for determining disease severity. In addition, the neutrophile-lymphocyte ratio can be used to rule out FG, especially in combination with other well-known clinical and diagnostic parameters.
dc.identifier.doi10.1515/tjb-2024-0038
dc.identifier.endpage508
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85202956619
dc.identifier.scopusqualityQ4
dc.identifier.startpage500
dc.identifier.urihttps://doi.org/10.1515/tjb-2024-0038
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29590
dc.identifier.volume49
dc.identifier.wosWOS:001256853200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWalter De Gruyter Gmbh
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcell population data
dc.subjectFournier gangrene
dc.subjectneutrophile reactivity
dc.subjectgranularity index
dc.subjectinfection
dc.titleUtilizing cell population data for diagnosis and intensive care unit requirement prediction in Fournier gangrene patients
dc.typeArticle

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