DEVELOPMENT OF HERBAL BIOACTIVE LOADED NANOPARTICLES FOR TOPICAL APPLICATION IN VITILIGO

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dc.authoridGurbuz Yurtsever, Asli/0000-0002-1389-1581
dc.contributor.authorAbdo, Luceyn
dc.contributor.authorEsenturk-Guzel, Imren
dc.contributor.authorTopuzoglu, Sehernaz
dc.contributor.authorYurtsever, Asli Gurbuz
dc.contributor.authorErdal, Meryem Sedef
dc.contributor.authorYapar, Evren Algin
dc.date.accessioned2024-10-26T18:08:07Z
dc.date.available2024-10-26T18:08:07Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractVitiligo is characterised by the appearance of white lesions on the skin, which are mainly caused by depigmentation of the skin due to the destruction of selective melanocytes. Ammi visnaga L. is a plant that grows widely in Mediterranean climate regions and khellin is one of its major components. Khellin stimulates the migration and proliferation of melanocytes in hair follicles. Both oral and dermal use of khellin is available, but some systemic side effects such as nausea and hepatotoxicity can be accompanied by oral administration. In the case of dermal application, poor skin penetration of khellin related to its lipophilicity needs to be overcome. In this study, khellin loaded cellulose acetate phthalate nanoparticles were developed to be used in the topical treatment of vitiligo by using Taguchi Orthogonal Array Design in the preliminary formulation studies. The characterization studies were carried out by determination of the size, zeta potential and encapsulation efficiency of nanoparticles and in vitro drug release and ex vivo penetration studies were carried out to evaluate their performance. The optimum nanoparticle formulation was found as an average size of 217.8 nm, PDI value of 0.11, zeta potential of -18.4 mV and encapsulation efficiency of 34.2%. Khellin loaded nanoparticles released 75% of khellin during 24 hours in a controlled manner. In addition, incorporation of khellin nanoparticles into HPMC gel increased the amount of khellin accumulated in the deep layers of the skin.
dc.description.sponsorshipTUBITAK (The Scientific and Technological Research Council of Turkiye) 2209-A program [1919B012101980]
dc.description.sponsorshipThis study was supported by TUBITAK (The Scientific and Technological Research Council of Turkiye) 2209-A program, project number: 1919B012101980.
dc.identifier.doi10.31925/farmacia.2023.6.22
dc.identifier.endpage1315
dc.identifier.issn0014-8237
dc.identifier.issn2065-0019
dc.identifier.issue6
dc.identifier.scopus2-s2.0-85181729933
dc.identifier.scopusqualityQ2
dc.identifier.startpage1305
dc.identifier.urihttps://doi.org/10.31925/farmacia.2023.6.22
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29824
dc.identifier.volume71
dc.identifier.wosWOS:001137201800010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSoc Stiinte Farmaceutice Romania
dc.relation.ispartofFarmacia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleDEVELOPMENT OF HERBAL BIOACTIVE LOADED NANOPARTICLES FOR TOPICAL APPLICATION IN VITILIGO
dc.typeArticle

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