Moderation analysis exploring associations between age and mucocutaneous activity in Behcet's syndrome: A multicenter study from Turkey

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dc.authoridMumcu, Gonca/0000-0002-2280-2931
dc.authoridTEKGOZ, Emre/0000-0002-0866-1503
dc.authoridKaradag, Omer/0000-0002-3443-3117
dc.authoridBadak, Suade ozlem/0000-0002-4661-787X
dc.authoridYILMAZ, Sedat/0000-0002-4691-3417
dc.authoridTAS, Mehmet Nedim/0000-0002-6818-6409
dc.authoridsahin, ali/0000-0003-0743-5288
dc.contributor.authorMumcu, Gonca
dc.contributor.authorYay, Meral
dc.contributor.authorKaracayli, Umit
dc.contributor.authorAksoy, Aysun
dc.contributor.authorTas, Mehmet Nedim
dc.contributor.authorArmagan, Berkan
dc.contributor.authorSari, Alper
dc.date.accessioned2024-10-26T18:11:43Z
dc.date.available2024-10-26T18:11:43Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractThe aim of the present study was to examine the effects of age on mucocutaneous activity by using moderation analysis in Behcet's syndrome (BS). In this cross-sectional study, 887 BS patients (female : male, 481:406; mean age, 38.4 +/- 10.9 years) followed in 13 tertiary centers in Turkey were included. Mucocutaneous activity was evaluated by using the Mucocutaneous Index (MI) according to sex and disease course. Moderation analysis was performed to test the effect of age on mucocutaneous activity. A moderator variable is a third variable and affects the relationship between independent and outcome variables. Age was chosen as a potential moderator variable (interaction effect), MI score as the outcome variable and sex as an independent variable in the analysis. The moderation analysis tested the effects of age in three steps: whole BS patient group, patients without systemic involvement and those with systemic involvement. The moderation model was only significant in BS patients with systemic involvement (P = 0.0351), and a significant relationship was observed between female sex and MI score (P = 0.0156). In addition, the interaction plot showed that female patients had increased MI scores compared with male patients, especially in the 28-year-old age group (P = 0.0067). Moreover, major organ involvement was newly diagnosed in the majority of these young female BS patients. Our results suggest that the relationship between sex and mucocutaneous activity was moderated by age in the systemic involvement group. Also, increased mucocutaneous activity may be associated with new major organ involvement in young female BS patients with systemic involvement.
dc.identifier.doi10.1111/1346-8138.15553
dc.identifier.endpage1410
dc.identifier.issn0385-2407
dc.identifier.issn1346-8138
dc.identifier.issue12
dc.identifier.pmid32981075
dc.identifier.scopus2-s2.0-85091444127
dc.identifier.scopusqualityQ1
dc.identifier.startpage1403
dc.identifier.urihttps://doi.org/10.1111/1346-8138.15553
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30774
dc.identifier.volume47
dc.identifier.wosWOS:000572763700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Dermatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBehcet's syndrome
dc.subjectmoderation analysis
dc.subjectmucocutaneous activity
dc.subjectMucocutaneous Index
dc.subjectsex
dc.titleModeration analysis exploring associations between age and mucocutaneous activity in Behcet's syndrome: A multicenter study from Turkey
dc.typeArticle

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