Factors Affecting Permanent Sensorineural Hearing Loss and Bone Conduction in Patients After Receiving Radiotherapy to the Head and Neck Region

Basit Öğe Kaydı
dc.authoridYucel, Birsen/0000-0002-0083-6866
dc.authoridAltuntas, Emine Elif/0000-0003-4503-3730
dc.contributor.authorYucel, Birsen
dc.contributor.authorErdis, Eda
dc.contributor.authorBahar, Seher
dc.contributor.authorAtasever, Ebru Akkas
dc.contributor.authorCelasun, Mustafa Guerol
dc.contributor.authorAltuntas, Emine Elif
dc.date.accessioned2024-10-26T18:00:44Z
dc.date.available2024-10-26T18:00:44Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: This study aimed to investigate the factors affecting permanent sensorineural hearing loss (SNHL) and causing changes in bone conduction (BC) thresholds over time in patients after receiving radiotherapy (RT) or chemoradiotherapy (CRT) to the head and neck region.Methods: A total of 63 patients with irradiated HNC that were admitted to the Radiation Oncology Department between 2011 and 2018 were included in the study. All patients were assessed with pure tone audiometry at eight different time points (first before RT and last five years after completion of RT). A chi-square test was used to analyze the variables that affected permanent SNHL occurrence. Repeated measure analysis of variance was conducted to investigate the factors affecting change in the BC threshold at pure-tone average (0.5-2 kHz) and the air conduction (AC) threshold at 4 and 6 kHz frequencies over time.Results: Median follow-up was 52 months (range, 12-110 months). SNHL was found in 18 (14%) of the 126 ears. According to the receiver operating characteristic analysis, the cut-off values of cochlear Dmean and Dmax 0.676] and 45 Gy (p=0.008, AUC: 0.695). Dmean (& LE;40 Gy vs. >40 Gy) and Dmax (& LE;45 Gy vs. >45 Gy) cochlear doses and age (& LE;40 vs. >40 years) were determined as factors affecting SNHL in the chi-square test. Repeated measures showed that BC thresholds between 0.5-2 kHz and AC thresholds at 4 and 6 kHz increased over time. Age (& LE;40 vs. >40 years), treatment of head and neck cancer (RT vs. CRT), cisplatin use, and Dmean (& LE;40 Gy vs. >40 Gy) and Dmax cochlear dose (& LE;45 Gy vs. >45 Gy) were important factors affecting the course of BC threshold over time. radiation doses were 40 Gy [p=0.017, area under the curve (AUC):Conclusion: D mean and Dmax cochlear doses and age were found to be associated with permanent SNHL. Conduction thresholds worsened over time at all frequencies, and this trend was affected by cochlear doses, age, CRT, and cisplatin use.
dc.identifier.doi10.4274/tao.2022.2022-6-2
dc.identifier.endpage219
dc.identifier.issn2667-7466
dc.identifier.issn2667-7474
dc.identifier.issue4
dc.identifier.pmid37456600
dc.identifier.startpage212
dc.identifier.trdizinid1188334
dc.identifier.urihttps://doi.org/10.4274/tao.2022.2022-6-2
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1188334
dc.identifier.urihttps://hdl.handle.net/20.500.12418/27834
dc.identifier.volume60
dc.identifier.wosWOS:001029513400006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.ispartofTurkish Archives of Otorhinolaryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHead and neck cancer
dc.subjectradiotherapy
dc.subjectchemoradiotherapy
dc.subjectside effect
dc.subjecthearing loss
dc.subjectradiation dose
dc.titleFactors Affecting Permanent Sensorineural Hearing Loss and Bone Conduction in Patients After Receiving Radiotherapy to the Head and Neck Region
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu