Synthesis, antimicrobial activity and molecular docking study of benzyl functionalized benzimidazole silver(I) complexes
| dc.contributor.author | Arı, Erkan | |
| dc.contributor.author | Şahin, Neslihan | |
| dc.contributor.author | Üstün, Elvan | |
| dc.contributor.author | Dündar, Muhammed | |
| dc.contributor.author | Karcı, Hüseyin | |
| dc.contributor.author | Özdemir, İlknur | |
| dc.contributor.author | Koç, Ahmet | |
| dc.contributor.author | Gürbüz, Nevin | |
| dc.contributor.author | Özdemir, İsmail | |
| dc.date.accessioned | 2024-03-06T06:14:59Z | |
| dc.date.available | 2024-03-06T06:14:59Z | |
| dc.date.issued | 2023 | tr |
| dc.department | Eğitim Bilimleri Enstitüsü | tr |
| dc.description.abstract | In this study, a series of N-functionalized benzimidazole silver(I) complexes were prepared and characterized by FT-IR, 1H, 13C{1H} NMR spectroscopy, and elemental analysis. Synthesized N-benzylbenzimidazole silver(I) complexes were evaluated for their antimicrobial activities against bacteria Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and the fungal strains Candida albicans and Candida glabrata. The results indicated that N-alkylbenzimidazole silver(I) complexes exhibited good antimicrobial activity compared to N-alkylbenzimidazole derivatives. Especially, complex 2e presented perfect antimicrobial activity than the other complexes. The characterized molecules were optimized by DFT-based calculation methods and the optimized molecules were analyzed in detail by molecular docking methods against bacterial DNA-gyrase and CYP51. The amino acid residues detected for both target molecules are consistent with expectations, and the calculated binding affinities and inhibition constants are promising for further studies. | tr |
| dc.identifier.pmid | 37934281 | en_US |
| dc.identifier.scopus | 2-s2.0-85175947503 | en_US |
| dc.identifier.scopusquality | N/A | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12418/14721 | |
| dc.identifier.wos | WOS:001100986900001 | en_US |
| dc.identifier.wosquality | Q2 | |
| dc.indekslendigikaynak | Web of Science | en_US |
| dc.indekslendigikaynak | Scopus | en_US |
| dc.indekslendigikaynak | PubMed | en_US |
| dc.language.iso | en | en_US |
| dc.relation.publicationcategory | Rapor | tr |
| dc.rights | info:eu-repo/semantics/openAccess | tr |
| dc.title | Synthesis, antimicrobial activity and molecular docking study of benzyl functionalized benzimidazole silver(I) complexes | en_US |
| dc.type | Article | en_US |
