Promising Insecticidal Properties of Essential Oils from Artemisia aragonensis Lam. and Artemisia negrei L. (Asteraceae) by Targeting Gamma-Aminobutyric Acid and Ryanodine Receptor Proteins: In Vitro and In Silico Approaches

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dc.authoridEl moussaoui, abdelfattah/0000-0001-5261-570X
dc.authoridAimad, Allali/0000-0001-6411-9033
dc.authoridTUZUN, BURAK/0000-0002-0420-2043
dc.authoridChalkha, Mohammed/0000-0002-9400-2183
dc.authoridchebbac, khalid/0000-0002-8511-6859
dc.authoridBIN JARDAN, YOUSEF/0000-0003-3302-4036
dc.contributor.authorChebbac, Khalid
dc.contributor.authorOuaritini, Zineb Benziane
dc.contributor.authorAllali, Aimad
dc.contributor.authorTuzun, Burak
dc.contributor.authorZouirech, Otmane
dc.contributor.authorChalkha, Mohammed
dc.contributor.authorEl Moussaoui, Abdelfattah
dc.date.accessioned2024-10-26T18:11:25Z
dc.date.available2024-10-26T18:11:25Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractArtemisia negrei (A. negrei) and Artemisia aragonensis (A. aragonensis) are in the family Asteraceae, which has been used in traditional medicine. The use of plant-derived insecticides has become a promising strategy to reduce the harmful effects of synthetic insecticides and overcome the bio-resistance of pest insects to insecticides. In this regard, the purpose of the current study was to determine the chemical composition and evaluate insecticidal effects of essential oils (EOs) extracted from A. negrei (EON) and A. aragonensis (EOA). Notably, all chemical constituents present in the EOs were identified through GC-MS analysis, whilst the insecticidal properties against Callosobruchus maculatus Fab. (C. maculatus) were investigated by use of in vitro an in silico approaches. The obtained results showed that both tested EOs present a significant insecticidal effect against C. maculatus, which increased significantly upon the dose used in both contact and inhalation tests. The lethal concentrations (LC50) for the inhalation test were found to be 2.1 and 2.97 mu L/L, while in the contact test they were 2.08 and 2.74 mu L/L of air for EON and EOA, respectively. At 5 mu L/L of air, the spawn reduction rate was 88.53 % and 77.41%, while the emergence reduction rate was 94.86% and 81.22% by EON and EOA, respectively. With increasing doses of up to 20 mu L/L of air, the reduction in individual emergence reached 100% by the two oils tested after 36 h of treatment. In addition, Molecular docking (MD) simulations supported the in vitro findings and indicated that certain identified components in EOA and EON exhibited stronger hydrogen bonding interactions with the target receptors. Interestingly, the prediction of ADMET properties indicates that the molecules investigated have great pharmacokinetic profiles with no side effects. Taken together, our findings suggest that EOA and EON may exert both potential contact and inhalation insecticidal actions and could be used as an alternative tool for the control of this major insect pest of stored products.
dc.description.sponsorshipKing Saud University, Riyadh, Saudi Arabia [RSP2023R457]; Scientific Research Project Fund of Sivas Cumhuriyet University (CUBAP), Turkey [RGD-020]
dc.description.sponsorshipThis work is financially supported by the Researchers Supporting Project (RSP2023R457). King Saud University, Riyadh, Saudi Arabia.
dc.identifier.doi10.3390/separations10060329
dc.identifier.issn2297-8739
dc.identifier.issue6
dc.identifier.scopus2-s2.0-85163765970
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.3390/separations10060329
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30666
dc.identifier.volume10
dc.identifier.wosWOS:001015588200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofSeparations
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectArtemisia negrei
dc.subjectArtemisia aragonensis
dc.subjectinsecticidal activity
dc.subjectmolecular docking
dc.subjectADMET properties
dc.titlePromising Insecticidal Properties of Essential Oils from Artemisia aragonensis Lam. and Artemisia negrei L. (Asteraceae) by Targeting Gamma-Aminobutyric Acid and Ryanodine Receptor Proteins: In Vitro and In Silico Approaches
dc.typeArticle

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