The Role of the CCR2 Gene Polymorphism in Abdominal Aortic Aneurysms

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dc.authoridYILMAZ, MEHMET BIRHAN -- 0000-0002-8169-8628en_US
dc.contributor.authorKatrancioglu, Nurkay
dc.contributor.authorManduz, Sinasi
dc.contributor.authorKarahan, Oguz
dc.contributor.authorYilmaz, Mehmet Birhan
dc.contributor.authorSezgin, Ilhan
dc.contributor.authorBagci, Gokhan
dc.contributor.authorBerkan, Ocal
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:06:00Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:06:00Z
dc.date.issued2011
dc.department[Katrancioglu, Nurkay -- Manduz, Sinasi -- Karahan, Oguz -- Berkan, Ocal] Cumhuriyet Univ, Sch Med, Dept Cardiovasc Surg, TR-58140 Sivas, Turkey -- [Yilmaz, Mehmet Birhan] Cumhuriyet Univ, Sch Med, Dept Cardiol, TR-58140 Sivas, Turkey -- [Sezgin, Ilhan -- Bagci, Gokhan] Cumhuriyet Univ, Sch Med, Dept Med Biol & Genet, TR-58140 Sivas, Turkeyen_US
dc.description.abstractObjective: Chronic inflammation play an important role on abdominal aortic aneurysms (AAA) formation. Chemokine receptor-2 (CCR2) is involved in regulation of the inflammatory response. However, relation between CCR2 polymorphism and AAA formation in human has not yet been investigated. In this study, we aimed to investigate the relationship between AAA and CCR2-V64I gene polymorphism. Methods: In this study, 100 consecutive patients with AAA and 138 individuals with normal aortic diameter were included. CCR2-V64I gene polymorphism were analyzed by PCR-RFLP technique. Genotype distribution and allele frequencies of CCR2-V64I gene polymorphism in patients with AAA and healthy subjects were compared. Results: CCR2 heterozygote V64I polymorphism and allele frequency were more frequently observed in the AAA group (p = 0.01, p = 0.004). Significant relationship was observed between CCR2 V64I polymorphism (OR:2.31, 95% CI:1.19-4.46, p = 0.01) and presence of AAA in multivariate regression analysis. Conclusion: The present study, showed us a relationship between CCR2-V64I polymorphism and AAA.en_US
dc.identifier.doi10.1177/0003319710385335en_US
dc.identifier.endpage143en_US
dc.identifier.issn0003-3197
dc.identifier.issue2en_US
dc.identifier.pmid21220372en_US
dc.identifier.scopus2-s2.0-78651384518en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage140en_US
dc.identifier.urihttps://dx.doi.org/10.1177/0003319710385335
dc.identifier.urihttps://hdl.handle.net/20.500.12418/9606
dc.identifier.volume62en_US
dc.identifier.wosWOS:000286071300007en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS INCen_US
dc.relation.ispartofANGIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectabdominal aortic aneurysmen_US
dc.subjectgenetic relationen_US
dc.subjectCCR2 gene polymorphismen_US
dc.titleThe Role of the CCR2 Gene Polymorphism in Abdominal Aortic Aneurysmsen_US
dc.typeArticleen_US

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