Evaluation of the Usability of a Rapid Antigen Test for the Diagnosis of COVID-19 Disease in Comparison with the Molecular Method

Basit Öğe Kaydı
dc.authoridcubuk, fatih/0000-0002-8976-7691
dc.authoridhasbek, mursit/0000-0002-5217-8607
dc.contributor.authorCubuk, Fatih
dc.contributor.authorKafa, Ayse Humeyra Taskin
dc.contributor.authorBaykus, Hatice Seyma
dc.contributor.authorHasbek, Mursit
dc.date.accessioned2024-10-26T18:00:45Z
dc.date.available2024-10-26T18:00:45Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractIntroduction: Rapid testing of patients with suspected COVID-19 disease is critical so that those infected can self-isolate and reduce the risk of SARS-CoV-2 spreading to the community. Our study aimed to assess the usability of a rapid antigen test kit for the diagnosis of COVID-19 by comparing it with the molecular method. Materials andMethods: Our study was planned retrospectively between 14 March and 14 August 2022. COVID-19 rapid antigen test and COVID-19 RT qPCR test results of patients who applied to our hospital with complaints compatible with COVID-19 disease during this period were included in the study.Results: A total of 268 patients were included in the study. According to the PCR test, the sensitivity was 92.6%, the specificity was 96.5%, and the accuracy was 95.1% for the rapid antigen test. Seven (2.6%) samples were identified as positive by the PCR test but negative by the rapid antigen test. The mean Ct value of these samples was detected as 26.38. According to the PCR test, the rapid antigen test positivity rate was 100% for 78 samples with a Ct value of <22, and the rapid antigen test was negative for two samples with a Ct value of >30.Conclusion: COVID-19 rapid antigen test kits can be utilized to rapidly detect and isolate symptomatic individuals, particularly during periods when there is a high number of cases. However, the sensitivity of the rapid antigen test is affected by the viral load of the sample. With rapid antigen test kits, there is a possibility of obtaining false negative results in samples with high Ct values or low viral loads. Therefore, we believe it would be beneficial to evaluate symptomatic individuals with negative rapid antigen test results using PCR.
dc.identifier.doi10.5578/flora.20239713
dc.identifier.endpage439
dc.identifier.issn1300-932X
dc.identifier.issn2602-2842
dc.identifier.issue3
dc.identifier.startpage433
dc.identifier.trdizinid1203877
dc.identifier.urihttps://doi.org/10.5578/flora.20239713
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1203877
dc.identifier.urihttps://hdl.handle.net/20.500.12418/27847
dc.identifier.volume28
dc.identifier.wosWOS:001084639100003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isotr
dc.publisherBilimsel Tip Yayinevi
dc.relation.ispartofFlora Infeksiyon Hastaliklari ve Klinik Mikrobiyoloji Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCOVID-19
dc.subjectSARS-CoV-2
dc.subjectCOVID-19 rapid antigen test
dc.subjectRT-qPCR
dc.titleEvaluation of the Usability of a Rapid Antigen Test for the Diagnosis of COVID-19 Disease in Comparison with the Molecular Method
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu