Analysis of ROMO1 Expression Levels and Its Oncogenic Role in Gastrointestinal Tract Cancers

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dc.authoridVATANSEVER, Mehmet/0009-0002-2019-1214
dc.contributor.authorYaman, Selcuk
dc.contributor.authorAkidan, Osman
dc.contributor.authorVatansever, Mehmet
dc.contributor.authorMisir, Sema
dc.contributor.authorYaman, Serap Ozer
dc.date.accessioned2025-05-04T16:45:43Z
dc.date.available2025-05-04T16:45:43Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractGastrointestinal tract cancers account for approximately one-third of cancer-related deaths. Early diagnosis and effective treatment are the most important ways to prevent cancer-related morbidity and mortality. ROMO1 has been shown to play an important role in many types of cancer. However, the biological function of ROMO1 is still poorly understood in gastrointestinal system cancers. The aim of this study is to reveal the expression change and oncogenic role of ROMO in gastrointestinal system cancers. Gene Expression Profiling Interactive Analysis (GEPIA), UALCAN, TIMER, GeneMANIA, TISIDB, and STRING were applied to assess the biological function of ROMO1 in gastrointestinal cancers (colon adenocarcinoma (COAD), esophageal carcinoma (ESCA), liver hepatocellular carcinoma (LIHC), pancreatic adenocarcinoma (PAAD), and stomach adenocarcinoma (STAD)). ROMO1 is significantly increased in COAD, ESCA, LUHC, and PAAD, and the overexpression of ROMO1 is associated with clinicopathological features. In addition, ROMO1 has been found to be closely associated with tumor-infiltrating immune cells in gastrointestinal cancers. ROMO1 is closely related to the inner mitochondrial membrane proteins (TIMM) family. The study revealed that ROMO1 is of significant clinical importance for gastrointestinal cancers and may have potential clinical utility in treatment and prognosis. Functional tests on cell lines derived from these particular gastrointestinal cancers can also be performed in vitro to evaluate the impact of the ROMO1 gene and other factors, like potential drugs, on the expression of these genes and the development and progression of the cancer.
dc.identifier.doi10.3390/cimb46120863
dc.identifier.endpage14407
dc.identifier.issn1467-3037
dc.identifier.issn1467-3045
dc.identifier.issue12
dc.identifier.pmid39727991
dc.identifier.scopus2-s2.0-85213435540
dc.identifier.scopusqualityQ3
dc.identifier.startpage14394
dc.identifier.urihttps://doi.org/10.3390/cimb46120863
dc.identifier.urihttps://hdl.handle.net/20.500.12418/35203
dc.identifier.volume46
dc.identifier.wosWOS:001383804700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMDPI
dc.relation.ispartofCurrent Issues in Molecular Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250504
dc.subjectROMO1
dc.subjectgastrointestinal cancers
dc.subjectimmune cells
dc.titleAnalysis of ROMO1 Expression Levels and Its Oncogenic Role in Gastrointestinal Tract Cancers
dc.typeArticle

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