Multicenter Epidemiologic Study on Hepatocellular Carcinoma in Turkey

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dc.contributor.authorCan, Alper
dc.contributor.authorDogan, Erkan
dc.contributor.authorBayoglu, Ibrahim Vedat
dc.contributor.authorTatli, Ali Murat
dc.contributor.authorBesiroglu, Mehmet
dc.contributor.authorKocer, Murat
dc.contributor.authorDulger, Ahmet Cumhur
dc.contributor.authorUyeturk, Ummugul
dc.contributor.authorKivrak, Derya
dc.contributor.authorOrakci, Zuat
dc.contributor.authorBal, Oznur
dc.contributor.authorKacan, Turgut
dc.contributor.authorOlmez, Sehmus
dc.contributor.authorTuran, Nedim
dc.contributor.authorOzbay, Mehmet Fatih
dc.contributor.authorAlacacioglu, Ahmet
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:58:02Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:58:02Z
dc.date.issued2014
dc.department[Can, Alper -- Dogan, Erkan -- Dulger, Ahmet Cumhur -- Olmez, Sehmus] Van Yuzuncu Yil Univ, Fac Med, Dept Med Oncol, Van, Turkey -- [Tatli, Ali Murat -- Ozbay, Mehmet Fatih] Reg Training & Res Hosp, Van, Turkey -- [Bayoglu, Ibrahim Vedat -- Alacacioglu, Ahmet] Katip Celebi Univ, Fac Med, Izmir, Turkey -- [Besiroglu, Mehmet] Marmara Univ, Fac Med, Istanbul, Turkey -- [Kocer, Murat] Sulayman Demirel Univ, Fac Med, Isparta, Turkey -- [Uyeturk, Ummugul] Abant Izzet Baysal Univ, Fac Med, Bolu, Turkey -- [Kivrak, Derya] Akdeniz Univ, Fac Med, TR-07058 Antalya, Turkey -- [Orakci, Zuat] Dicle Univ, Fac Med, Diyarbakir, Turkey -- [Bal, Oznur] Reg Training & Res Hosp, Ankara, Turkey -- [Kacan, Turgut] Cumhuriyet Univ, Fac Med, Sivas, Turkey -- [Turan, Nedim] Reg Training & Res Hosp, Malatya, Turkeyen_US
dc.description.abstractBackground: Hepatocellular cancer (HCC) is one of the important health problems in Turkey, being very common and highly lethal. The aim of this study was to determine clinical, demographic features and risk factors. Materials and Methods: Nine hundred and sixth-three patients with HCC from 13 cities in Turkey were included in this study. Results: Only 205 (21%) of the 963 patients were women, with a male: female predominance of 4.8:1 and a median age of 61 years. The etiologic risk factors for HCC were hepatitis B in 555 patients (57.6%), 453 (81%) in men, and 102 (19%) in women, again with male predominance, hepatitis C in 159 (16.5%), (14.9% and 22.4%, with a higher incidence in women), and chronic alcohol abuse (more than ten years) in 137 (14.2%) (16.8% and 4.9%, higher in males). The Child-Pugh score paralleled with advanced disease stage amd also a high level of AFP. Conclusions: According to our findings the viral etiology (hepatitis B and hepatitis C infections) in the Turkish population was the most important factor in HCC development, with alcohol abuse as the third risk factor. The Child-Pugh classification and AFP levels were determined to be important prognostic factors in HCC patients.en_US
dc.identifier.doi10.7314/APJCP.2014.15.6.2923en_US
dc.identifier.endpage2927en_US
dc.identifier.issn1513-7368
dc.identifier.issue6en_US
dc.identifier.pmid24761926en_US
dc.identifier.scopus2-s2.0-84899844040en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage2923en_US
dc.identifier.urihttps://dx.doi.org/10.7314/APJCP.2014.15.6.2923
dc.identifier.urihttps://hdl.handle.net/20.500.12418/8423
dc.identifier.volume15en_US
dc.identifier.wosWOS:000335651700087en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherASIAN PACIFIC ORGANIZATION CANCER PREVENTIONen_US
dc.relation.ispartofASIAN PACIFIC JOURNAL OF CANCER PREVENTIONen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHepatocellular carcinomaen_US
dc.subjectetiologic factorsen_US
dc.subjectalpha-fetoproteinen_US
dc.subjectTurkeyen_US
dc.titleMulticenter Epidemiologic Study on Hepatocellular Carcinoma in Turkeyen_US
dc.typeArticleen_US

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