High prolidase levels in patients with Familial Mediterranean Fever (FMF)

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dc.authoridSAHIN, ALI/0000-0002-6953-4276
dc.contributor.authorBayram, Meliha
dc.contributor.authorDerin, Mehmet Emin
dc.contributor.authorDogan, Halef Okan
dc.contributor.authorAsan, Gokmen
dc.contributor.authorSahin, Mehtap
dc.contributor.authorSahin, Ali
dc.date.accessioned2024-10-26T18:05:19Z
dc.date.available2024-10-26T18:05:19Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractIntroduction. Familial Mediterranean Fever (FMF) is an autoinflammatory disease. Prolidase is a specific imidodipeptidase that plays a role in collagen degradation, and an important role in inflammation and wound healing. Hypoxia-inducible factor-1 alpha (HIF-1) is an important protein in the regulation of immunological response, hemostasis, vascularization. The aim of the study was to compare serum prolidase and HIF-1 alpha levels in patients with FMF in attack-free period and healthy control group. Methods. Between August 2017 and December 2017, sixty patients diagnosed with FMF according to the criteria of the Tel-hashomer and admitted to Sivas Cumhuriyet University Medical Faculty, Internal Medicine Rheumatology Department and sixty healthy volunteers were enrolled in the study. Results. Median serum prolidase levels were 72.1 (25.1-114.9) ng/ml in FMF group and 30.7 (21.3-86.2) ng/mL in healthy control (HC) group (p = 0.018). ROC analysis showed that the sensitivity was 65% and the specificity was 68.3% at serum prolidase levels 54.03 ng/mL (p < 0.05). The median serum levels of HIF-1 alpha in the FMF group was 482.0 (292.0-3967.0) pg/mL and 632.0 (362.0-927.0) pg/mL in the HC group (p > 0.05). There was no significant correlation between laboratory findings, sex, age, and prolidase (p > 0.05). Conclusion. Serum prolidase enzyme levels in FMF patients with attack-free period were significantly higher than in the HC group. However, the role of prolidase and HIF1-alpha in the FMF disease needs to be clarified with more extensive and comprehensive studies.
dc.description.sponsorshipCumhuriyet University Scientific Research Projects (CUBAP) Commission [T-744]
dc.description.sponsorshipThis study was supported by Cumhuriyet University Scientific Research Projects (CUBAP) Commission (Project Number: T-744)
dc.identifier.doi10.2478/rjim-2019-0025
dc.identifier.endpage33
dc.identifier.issn1582-3296
dc.identifier.issn2501-062X
dc.identifier.issue1
dc.identifier.pmid31846428
dc.identifier.scopus2-s2.0-85081944054
dc.identifier.scopusqualityQ3
dc.identifier.startpage27
dc.identifier.urihttps://doi.org/10.2478/rjim-2019-0025
dc.identifier.urihttps://hdl.handle.net/20.500.12418/28936
dc.identifier.volume58
dc.identifier.wosWOS:000519292900005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSciendo
dc.relation.ispartofRomanian Journal of Internal Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFamilial Mediterranean Fever (FMF)
dc.subjectprolidase
dc.subjectHIF-1 alpha
dc.titleHigh prolidase levels in patients with Familial Mediterranean Fever (FMF)
dc.typeArticle

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