Molecular epidemiological investigation of carbapenem resistant Klebsiella pneumoniae isolated from intensive care unit patients of six geographical regions of Turkey

Basit Öğe Kaydı
dc.authoridSahin, Merve/0000-0002-9847-6845
dc.authoridDURMAZ, RIZA/0000-0001-6561-778X
dc.authoridSesli Cetin, Emel/0000-0001-5231-3824
dc.authoridKulahlioglu, Neslihan/0000-0002-2579-1932
dc.authoridBUYUKTUNA, SEYIT ALI/0000-0001-6518-7361
dc.authoridCIGDEM, ARABACI/0000-0003-0050-3225
dc.authoridAri, Oguz/0000-0003-4930-5035
dc.contributor.authorKose, Sukran
dc.contributor.authorDal, Tuba
dc.contributor.authorCetinkaya, Riza Aytac
dc.contributor.authorAri, Oguz
dc.contributor.authorYenilmez, Ercan
dc.contributor.authorTemel, Esra Nurlu
dc.contributor.authorCetin, Emel Sesli
dc.date.accessioned2024-10-26T18:11:31Z
dc.date.available2024-10-26T18:11:31Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractIntroduction: Klebsiella pneumonia causes serious infections in hospitalized patients. In recent years, carbapenem-resistant infections increased in the world. The molecular epidemiological investigation of carbapenem-resistant K. pneumoniae isolates was aimed in this study.Methodology: Fifty carbapenem-resistant K. pneumoniae isolates from six geographical regions of Turkey between September 2019-2020 were included in the study. The disk diffusion method was used for the antibiotic susceptibility testing. The microdilution confirmed colistin susceptibility. Genetic diversity was investigated by MLST (Multi-Locus Sequence Typing).Results: The resistance rates were as follows: 49 (98%) for meropenem, 47 (94%) imipenem, 50 (100%) ertapenem, 30 (60%) colistin and amoxicillin-clavulanate, 49 (98%) ceftriaxone, 48 (96%) cefepime, 50 (100%) piperacillin-tazobactam, 47 (94%) ciprofloxacin, 40 (80%) amikacin, 37 (74%) gentamicin. An isolate resistant to colistin by disk diffusion was found as susceptible to microdilution. ST 2096 was the most common (n:16) sequence type by MLST. ST 101 (n:7), ST14 (n:6), ST 147 and ST 15 (n:4), ST391 (n:3), ST 377 and ST16 (n:2), ST22, ST 307, ST 985, ST 336, ST 345, and ST 3681 (n:1) were classified in other isolates. In Istanbul and Ankara ST2096 was common. Among Turkey isolates, the most common clonal complexes (CC) were CC14 (n:26) and CC11 (n = 7).Conclusions: In Turkey, a polyclonal population of CC14 throughout the country and inter-hospital spread were indicated. The use of molecular typing tools will highlight understanding the transmission dynamics.
dc.description.sponsorshipTurkish Republic Health Sciences University Research Foundation [2019/108]
dc.description.sponsorshipFunding This project was supported by Turkish Republic Health Sciences University Research Foundation (Project Number: 2019/108) .
dc.identifier.doi10.3855/jidc.17651
dc.identifier.endpage1451
dc.identifier.issn1972-2680
dc.identifier.issue10
dc.identifier.pmid37956378
dc.identifier.scopus2-s2.0-85176888445
dc.identifier.scopusqualityQ3
dc.identifier.startpage1446
dc.identifier.urihttps://doi.org/10.3855/jidc.17651
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30714
dc.identifier.volume17
dc.identifier.wosWOS:001104666000001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherJ Infection Developing Countries
dc.relation.ispartofJournal of Infection in Developing Countries
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectK. pneumonia
dc.subjectMLST
dc.subjectcarbapenem
dc.subjectcolistin
dc.titleMolecular epidemiological investigation of carbapenem resistant Klebsiella pneumoniae isolated from intensive care unit patients of six geographical regions of Turkey
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksyonu
Scopus İndeksli Yayınlar Koleksiyonu