Exploring free amino acid profiles in CCHF patients: Implications for disease progression

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dc.authoridKochan, Necla/0000-0003-2355-4826
dc.authoridBagci, Gokhan/0000-0003-4554-2391
dc.authoridYerlitas, Serra Ilayda/0000-0003-2830-3006
dc.authoridDOGAN, Kubra/0000-0002-9448-3407
dc.contributor.authorBuyuktuna, Seyit Ali
dc.contributor.authorYerlitas, Serra Ilayda
dc.contributor.authorZararsiz, Gozde Ertuk
dc.contributor.authorDogan, Kubra
dc.contributor.authorKablan, Demet
dc.contributor.authorBagci, Gokhan
dc.contributor.authorOzer, Selda
dc.date.accessioned2024-10-26T18:11:20Z
dc.date.available2024-10-26T18:11:20Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractThis study investigated the intricate interplay between Crimean-Congo hemorrhagic fever virus (CCHFV) infection and alterations in amino acid metabolism. Our primary aim is to elucidate the impact of Crimean-Congo hemorrhagic fever (CCHF) on specific amino acid concentrations and identify potential metabolic markers associated with viral infection. One hundred ninety individuals participated in this study, comprising 115 CCHF patients, 30 CCHF negative patients, and 45 healthy controls. Liquid chromatography-tandem mass spectrometry techniques were employed to quantify amino acid concentrations. The amino acid metabolic profiles in CCHF patients exhibit substantial distinctions from those in the control group. Patients highlight distinct metabolic reprogramming, notably characterized by arginine, histidine, taurine, glutamic acid, and glutamine metabolism shifts. These changes have been associated with the underlying molecular mechanisms of the disease. Exploring novel therapeutic and diagnostic strategies addressing specific amino acids may offer potential means to mitigate the severity of the disease.
dc.description.sponsorshipBilimsel Arastirma Projeleri, Erciyes niversitesi
dc.description.sponsorshipNo Statement Available
dc.identifier.doi10.1002/jmv.29672
dc.identifier.issn0146-6615
dc.identifier.issn1096-9071
dc.identifier.issue5
dc.identifier.pmid38751159
dc.identifier.scopus2-s2.0-85193380919
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1002/jmv.29672
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30627
dc.identifier.volume96
dc.identifier.wosWOS:001232031300026
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Medical Virology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectamino acid
dc.subjectCrimean-Congo hemorrhagic fever
dc.subjectLC-MS/MS
dc.subjectseverity
dc.titleExploring free amino acid profiles in CCHF patients: Implications for disease progression
dc.typeArticle

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