Superoxide Dismutase 1 (SOD 1) A251G Polymorphism

Basit Öğe Kaydı
dc.authoridSari, Ismail -- 0000-0003-3732-2102en_US
dc.contributor.authorSilig, Yavuz
dc.contributor.authorTas, Ayca
dc.contributor.authorSahin-Bolukbasi, Serap
dc.contributor.authorCaglayan, Gulcin
dc.contributor.authorSari, Ismail
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:41:30Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:41:30Z
dc.date.issued2017
dc.department[Silig, Yavuz -- Caglayan, Gulcin -- Sari, Ismail] Cumhuriyet Univ, Dept Biochem, Fac Med, TR-58140 Sivas, Turkey -- [Tas, Ayca] Cumhuriyet Univ, Dept Nutr & Diet, Fac Hlth Sci, Sivas, Turkey -- [Sahin-Bolukbasi, Serap] Cumhuriyet Univ, Dept Biochem, Fac Pharm, Sivas, Turkeyen_US
dc.description.abstractObjective: A genetic polymorphism of SOD1 A251G(rs2070424) is in the 3rd intron region of the SOD gene. The aim of this study was to determine the frequencies of the polymorphisms of the SOD1 A251G in a Turkish population, including 494 healthy individuals. Methods: The 494 Turkish individuals were genotyped for polymorphisms of SOD1 gene. The distribution of SOD1 A251G polymorphisms in this population was examined using a PCR-RFLP method. Genotype and allele frequencies were estimated by counting. Hardy-Weinberg equation between expected and observed genotype distributions was assessed using the X-2 test. Results: In the present study, the distribution of SOD1 A251G polymorphisms in a Turkish population including 494 (females: 278, 56.3% and males: 216, 43.7%) healthy individuals was examined. The mean age of the study population was 38.4 +/- 16.6 years (males, 39.8 +/- 17.1; females, 37.3 +/- 16.1). The observed genotype frequencies of SOD1 A251G were 86.2, 13.4 and 0.4% for AA, AG and GG, respectively. Conclusions: This study provides basic information about the allele and genotype frequency distributions of polymorphisms in the SOD1 A251G gene studied. These frequencies may be useful parameters as a reference for future studies on genetic basis of various diseases and cancer susceptibility.en_US
dc.identifier.doi10.1515/tjb-2016-0261en_US
dc.identifier.endpage185en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85020410213en_US
dc.identifier.scopusqualityQ4
dc.identifier.startpage181en_US
dc.identifier.urihttps://dx.doi.org/10.1515/tjb-2016-0261
dc.identifier.urihttps://hdl.handle.net/20.500.12418/6812
dc.identifier.volume42en_US
dc.identifier.wosWOS:000405114700008en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWALTER DE GRUYTER GMBHen_US
dc.relation.ispartofTURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCopper/zinc-superoxide dismutaseen_US
dc.subjectSuperoxide dismutase 1en_US
dc.subjectGenetic polymorphismen_US
dc.subjectTurkish populationen_US
dc.subjectSOD1 A251Gen_US
dc.subjectrs2070424en_US
dc.titleSuperoxide Dismutase 1 (SOD 1) A251G Polymorphismen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu