Novel ultra-stretchable and self-healing crosslinked poly (ethylene oxide)-cationic guar gum hydrogel

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dc.authorid0000-0003-0319-6312tr
dc.contributor.authorSönmez Gürer, Eda
dc.contributor.authorAlberto Bernal‑Chávez, Sergio
dc.contributor.authorAlcalá‑Alcalá Sergio
dc.contributor.authorM. Almarhoon, Zainab
dc.contributor.authorTurgumbayeva, Aknur
dc.contributor.authorDe Los Dolores, Campos‑Echeverria Ma
dc.contributor.authorCortes, Hernan
dc.contributor.authorRomero‑Montero, Alejandra
dc.contributor.authorDel Prado‑Audelo9, Maria Luise
dc.contributor.authorSharifi-Rad Javad
dc.contributor.authorLeyva‑Gómez Gerardo
dc.date.accessioned2024-03-06T06:15:56Z
dc.date.available2024-03-06T06:15:56Z
dc.date.issuedEkim 2023tr
dc.departmentEczacılık Fakültesitr
dc.description.abstractAbstractHydrogels are three-dimensional structures with specific features that render them useful for biomedical applications, such as tissue engineering scaffolds, drug delivery systems, and wound dressings. In recent years, there has been a significant increase in the search for improved mechanical properties of hydrogels derived from natural products to extend their applications in various fields, and there are different methods to obtain strengthened hydrogels. Cationic guar gum has physicochemical properties that allow it to interact with other polymers and generate hydrogels. This study aimed to develop an ultra-stretchable and self-healing hydrogel, evaluating the influence of adding PolyOX [poly(ethylene oxide)] on the mechanical properties and the interaction with cationic guar gum for potential tissue engineering applications. We found that variations in PolyOX concentrations and pH changes influenced the mechanical properties of cationic guar gum hydrogels. After optimization experiments, we obtained a novel hydrogel, which was semi-crystalline, highly stretchable, and with an extensibility area of approximately 400 cm2, representing a 33-fold increase compared to the hydrogel before being extended. Moreover, the hydrogel presented a recovery of 96.8% after the self-healing process and a viscosity of 153,347 ± 4,662 cP. Therefore, this novel hydrogel exhibited optimal mechanical and chemical properties and could be suitable for a broad range of applications in different fields, such as tissue engineering, drug delivery, or food storage.tr
dc.identifier.doi10.1186/s13036-023-00376-2en_US
dc.identifier.issn1754-1611
dc.identifier.pmid37845737en_US
dc.identifier.scopus2-s2.0-85174294520en_US
dc.identifier.scopusqualityQ1
dc.identifier.urihttp://dx.doi.org/10.1186/s13036-023-00376-2
dc.identifier.urihttps://hdl.handle.net/20.500.12418/14722
dc.identifier.volume17tr
dc.identifier.wosWOS:001086772800001en_US
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Biological Engineeringen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıtr
dc.rightsinfo:eu-repo/semantics/openAccesstr
dc.titleNovel ultra-stretchable and self-healing crosslinked poly (ethylene oxide)-cationic guar gum hydrogelen_US
dc.typeArticleen_US

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