Development of a new magnetic solid-phase extraction method prior to HPLC determination of naproxen in pharmaceutical products and water samples

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dc.authoridOymak, Tulay/0000-0001-5820-1364
dc.contributor.authorKaratas, Aysenur
dc.contributor.authorOymak, Tulay
dc.contributor.authorCelik, Ahmet
dc.date.accessioned2024-10-26T18:05:40Z
dc.date.available2024-10-26T18:05:40Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractIn this study, a new magnetic solid phase extraction based on magnetic composite modified with biochar obtained from pumpkin peel was developed for the enrichment and extraction of Naproxen in lake water, tablet and urine samples. The effects of main parameters such as pH, extraction time, amount of adsorbent and sample volume, which affect magnetic solid phase extraction, were investigated. Under optimal conditions, intraday and interday precision values for naproxen were below 5.9, with accuracy (relative error) better than 7.0 %. The detection limit and preliminary concentration factor were 12 ng/mL and 10, respectively. The method proposed here can be used for routine analysis of naproxen in lake water, urine and tablets.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [2209-A]
dc.description.sponsorshipThis study was funded by The Scientific and Technological Research Council of Turkey (TUBITAK) under the Programme called 2209-A University Students Research Projects Support Program. The HPLC used in this study was donated by Sanofi. Therefore, we would like to thank all the staff at Sanofi for their support and their collaboration.
dc.identifier.doi10.1016/j.jpba.2024.116336
dc.identifier.issn0731-7085
dc.identifier.issn1873-264X
dc.identifier.pmid38981249
dc.identifier.scopus2-s2.0-85198207588
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.jpba.2024.116336
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29131
dc.identifier.volume249
dc.identifier.wosWOS:001267845200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Pharmaceutical and Biomedical Analysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectNaproxen
dc.subjectMagnetic biochar
dc.subjectPumpkin peel
dc.subjectMagnetic solid-phase extraction
dc.subjectPharmaceutical contamination
dc.subjectHPLC
dc.titleDevelopment of a new magnetic solid-phase extraction method prior to HPLC determination of naproxen in pharmaceutical products and water samples
dc.typeArticle

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