Adverse effects of oxytetracycline and enrofloxacin on the fertility of Saanen bucks

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dc.authoridUSLU, Baris Atalay/0000-0003-1866-932X
dc.authoridKosal, Volkan/0000-0001-5268-5046
dc.authoridmercan yucel, ufuk/0000-0001-8256-7868
dc.contributor.authorYucel, Ufuk Mercan
dc.contributor.authorKosal, Volkan
dc.contributor.authorKara, Mikail
dc.contributor.authorTaspinar, Filiz
dc.contributor.authorUslu, Baris Atalay
dc.date.accessioned2024-10-26T18:09:39Z
dc.date.available2024-10-26T18:09:39Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractThis study aimed to determine the adverse effects of oxytetracycline and enrofloxacin application on the fertility of Saanen bucks. For this purpose, twenty-four bucks were divided into three groups. Group I (control group) received only 5 ml of 0.9% NaCl for 7 days, group II was given a single dose of 20 mg/kg oxytetracycline and group III was given at a dose of 2.5 mg/kg per day for 7 days intramuscularly. Serum and semen samples were collected from the bucks at post-treatment 1, 3, 5, 7, and 9 days and examined spermatological parameters (quantity, motility, density, abnormal sperm ratio, and live-dead sperm ratio), serum testosterone levels (with ELISA) and sperm DNA parameters (with Comet assay). The results showed no change in sperm volume, abnormal sperm rate, and dead-live sperm ratio in group II and III following oxytetracycline and enrofloxacin administration. However, a decrease in sperm density, sperm motility, mass activity, and testosterone levels, and an increase in sperm DNA damage were detected. These spermatological parameters (density, motility, mass activity) and testosterone levels were less decreased and sperm DNA damage was less increased in group II than group III. The greater damage in group III may be attributed to the longer duration of enrofloxacin administration compared to oxytetracycline and the effect of enrofloxacin on DNA. The results obtained from this study suggest that usage of oxytetracycline and especially enrofloxacin should be restricted and antibiotics with fewer side effects on sperm should be preferred in Saanen bucks during the reproduction period.
dc.identifier.doi10.1007/s11250-021-02898-7
dc.identifier.issn0049-4747
dc.identifier.issn1573-7438
dc.identifier.issue5
dc.identifier.pmid34546445
dc.identifier.scopus2-s2.0-85115216534
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s11250-021-02898-7
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30202
dc.identifier.volume53
dc.identifier.wosWOS:000698422200001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofTropical Animal Health and Production
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectOxytetracycline
dc.subjectEnrofloxacin
dc.subjectSaanen buck
dc.subjectSperm DNA damage
dc.subjectSpermatological parameters
dc.subjectTestosterone
dc.titleAdverse effects of oxytetracycline and enrofloxacin on the fertility of Saanen bucks
dc.typeArticle

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