Cytotoxic effects, carbonic anhydrase isoenzymes, ?-glycosidase and acetylcholinesterase inhibitory properties, and molecular docking studies of heteroatom-containing sulfonyl hydrazone derivatives

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dc.authoridCelebioglu, Hasan Ufuk/0000-0001-7207-2730
dc.authoridTUZUN, BURAK/0000-0002-0420-2043
dc.authoridGulcin, ilhami/0000-0001-5993-1668
dc.authoridErden, Yavuz/0000-0002-2807-6096
dc.authoridTaslimi, Parham/0000-0002-3171-0633
dc.authoridOzdemir Ozmen, ummuhan/0000-0001-9161-9367
dc.contributor.authorCelebioglu, Hasan Ufuk
dc.contributor.authorErden, Yavuz
dc.contributor.authorHamurcu, Fatma
dc.contributor.authorTaslimi, Parham
dc.contributor.authorSenturk, Ozan Sanli
dc.contributor.authorOzmen, Ummuhan Ozdemir
dc.contributor.authorTuzun, Burak
dc.date.accessioned2024-10-26T18:11:18Z
dc.date.available2024-10-26T18:11:18Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractToday, interest in studies on the search for new drugs to be used in diseases such as cancer, cardiovascular diseases, neurodegenerative diseases and diabetes, as well as prevention of microbial inflammation is increasing day by day. Emerging biological and pharmacological effects of sulfonyl hydrazone derivative compounds reveal their importance. In the present study, heteroatom-containing sulfonyl hydrazone derivatives have been studied for their anticancer and antimicrobial properties, as well as their effects on enzymes that could play roles in Alzheimer's dissease and diabetes. High doses of the tested compounds significantly decreased the cell viabilities of breast cancer (MCF-7) and prostate cancer (PC-3) cell lines. Furthermore, all compounds possessed antimicrobial activities against very common bacteriaE. coliandS. aureus. These compounds were good inhibitors of the alpha-glycosidase, human carbonic anhydrase I and II isoforms and acetylcholinesterase enzyme withK(i)values in the range of 1.14 +/- 0.14-3.63 +/- 0.26 nM for alpha-glycosidase, 66.05 +/- 9.21-125.45 +/- 11.54 nM for hCA I, 89.14 +/- 10.43-170.22 +/- 26.05 nM for hCA II and 754.03 +/- 73.22-943.92 +/- 58.15 nM for AChE, respectively. Molecular docking method was used to theoretically compare biological activities of sulfonyl hydrazone derivatives against enzymes. The theoretical results were compared with the experimental results. Thus, these compounds have strong biological activities. Communicated by Ramaswamy H. Sarma
dc.identifier.doi10.1080/07391102.2020.1792345
dc.identifier.endpage5550
dc.identifier.issn0739-1102
dc.identifier.issn1538-0254
dc.identifier.issue15
dc.identifier.pmid32691677
dc.identifier.scopus2-s2.0-85088393029
dc.identifier.scopusqualityQ2
dc.identifier.startpage5539
dc.identifier.urihttps://doi.org/10.1080/07391102.2020.1792345
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30604
dc.identifier.volume39
dc.identifier.wosWOS:000550699600001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Biomolecular Structure & Dynamics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHeteroatom
dc.subjectsulfonyl hydrazone
dc.subjectanticancer
dc.subjectantibacterial
dc.subjectenzyme inhibition
dc.subjectdocking
dc.titleCytotoxic effects, carbonic anhydrase isoenzymes, ?-glycosidase and acetylcholinesterase inhibitory properties, and molecular docking studies of heteroatom-containing sulfonyl hydrazone derivatives
dc.typeArticle

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