From biopolymer matrix to medicine: the drug delivery dynamics of amoxicillin-loaded PVA/SA/ZnONPs hydrogels

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dc.authoridArslan, Saynur/0009-0009-8675-8472
dc.contributor.authorAbuhamed, Nader
dc.contributor.authorArslan, Saynur
dc.contributor.authorOksuz, Kerim Emre
dc.contributor.authorDincer, Emine
dc.date.accessioned2024-10-26T18:05:26Z
dc.date.available2024-10-26T18:05:26Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractThis research presents a comprehensive study of Polyvinyl alcohol/Sodium alginate/Zinc oxide nanoparticles (PVA/SA/ZnONPs) and PVA/SA/ZnONPs/Amoxicillin (AMX) hydrogels, demonstrating their potential for various biomedical applications. A comparative analysis of their swelling behavior, in vitro biodegradation, antibacterial properties, and drug release profiles was performed. The hydrogels demonstrated distinct swelling characteristics, with the PVA/SA/ZnONPs/AMX hydrogel showing a higher initial swelling ratio. This behavior, likely due to the increased hydrophilicity from AMX, subsequently decreased over time, indicating AMX release into the environment. The biodegradation study highlighted a faster degradation rate for the PVA/SA/ZnONPs/AMX hydrogel, suggesting its suitability for applications requiring rapid degradation, such as drug delivery systems. Regarding antibacterial properties, the PVA/SA/ZnONPs/AMX hydrogel showed significant antibacterial activity against both Escherichia coli and Staphylococcus aureus, making it a strong candidate for biomedical applications necessitating antibacterial activity. Additionally, the drug release study presented a gradual and controlled release of AMX from the hydrogels over time, demonstrating their potential for sustained drug delivery applications. This research underscores the potential of PVA/SA/ZnONPs/AMX hydrogel, particularly for biomedical applications, especially in wound healing and drug delivery domains, given its potent antibacterial properties and controlled drug release behavior.
dc.identifier.doi10.1080/00914037.2024.2351851
dc.identifier.issn0091-4037
dc.identifier.issn1563-535X
dc.identifier.scopus2-s2.0-85194944702
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1080/00914037.2024.2351851
dc.identifier.urihttps://hdl.handle.net/20.500.12418/28973
dc.identifier.wosWOS:001236943200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofInternational Journal of Polymeric Materials and Polymeric Biomaterials
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntibacterial property
dc.subjectbiopolymers
dc.subjectdrug delivery
dc.subjecthydrogels
dc.subjectZnO
dc.titleFrom biopolymer matrix to medicine: the drug delivery dynamics of amoxicillin-loaded PVA/SA/ZnONPs hydrogels
dc.typeArticle

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