The Relation Between Angiotensin Converting Enzyme Gene Polymorphism and Renal Scarring with Vesicoureteral Reflux

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dc.authoridKoyluoglu, Gokhan/0000-0002-1140-169X
dc.contributor.authorDumlupmar, Yusuf
dc.contributor.authorCankorkmaz, Levent
dc.contributor.authorKoyluoglu, Gokhan
dc.contributor.authorOzdemir, Ozturk
dc.contributor.authorGuney, Cengiz
dc.date.accessioned2024-10-26T18:03:32Z
dc.date.available2024-10-26T18:03:32Z
dc.date.issued2010
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjectives: Vesicoureteral reflux (VUR) is the retrograde flow of urine from the bladder to the ureter. With its pivotal role in the Renin-Angiotensin-Aldosteron System, Angiotensin Converting Enzyme(ACE) is an exopeptidase that has an effect in many direct or indirect physiological and metabolic events. The aim of this study was to investigate whether the ACE gene I/D polymorphism is a risk factor for reflux nephropathy in children with VUR. Patients and Methods: The study included 53 (29 girls, 24 boys) patients with VUR and sixty healthy children constituted the control group. ACE genotypes were determined as II, ID, and DD using the polymerase chain reaction. Technetium-m99-dimercaptosuccinic acid scanning was performed for all patients. The association among the groups was analyzed using chi-square test. Results: There was no difference between the groups with and without reflux nephropathy regarding age at diagnosis of VUR, associated urological abnormalities, frequency of urinary tract infection episodes and the occurrence of bilateral or unilateral VUR. The ACE I/D genotype distribution were similar between the patient and the control groups and in patients with reflux nephropathy and those without reflux nephropathy. Conclusion: ACE gene I/D polymorphism is an independent prognostic indicator of reflux nephropathy inpatients with VUR.
dc.identifier.endpage182
dc.identifier.issn2149-2247
dc.identifier.issn2149-2549
dc.identifier.issue3
dc.identifier.scopus2-s2.0-77957324465
dc.identifier.scopusqualityN/A
dc.identifier.startpage177
dc.identifier.urihttps://hdl.handle.net/20.500.12418/28406
dc.identifier.volume32
dc.identifier.wosWOS:000421179400005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isotr
dc.publisherAves
dc.relation.ispartofErciyes Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPolymorphism
dc.subjectGenetics
dc.subjectVesico-Ureteral Reflux
dc.titleThe Relation Between Angiotensin Converting Enzyme Gene Polymorphism and Renal Scarring with Vesicoureteral Reflux
dc.typeArticle

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