Metal contained Phthalocyanines with 3,4-Dimethoxyphenethoxy substituents: their anticancer, antibacterial activities and their inhibitory effects on some metabolic enzymes with molecular docking studies

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dc.authoridGunay, Sevilay/0000-0002-0130-5629
dc.authoridTUZUN, BURAK/0000-0002-0420-2043
dc.authoridTaslimi, Parham/0000-0002-3171-0633
dc.authoridCelebioglu, Hasan Ufuk/0000-0001-7207-2730
dc.authoridErden, Yavuz/0000-0002-2807-6096
dc.authoridGulcin, ilhami/0000-0001-5993-1668
dc.contributor.authorTaslimi, Parham
dc.contributor.authorTurkan, Fikret
dc.contributor.authorGungordu Solgun, Derya
dc.contributor.authorAras, Abdulmelik
dc.contributor.authorErden, Yavuz
dc.contributor.authorCelebioglu, Hasan Ufuk
dc.contributor.authorTuzun, Burak
dc.date.accessioned2024-10-26T18:11:04Z
dc.date.available2024-10-26T18:11:04Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractThe compounds (3-6) used in this study were re-synthesized in accordance with our previous study. The inhibitory effect of the complexes on some metabolic enzymes was examined and it was demonstrated that the enzymes inhibited by ligands and their complex molecules at micromolar level. The best Ki value for alpha-glycosidase enzyme was absorved 1.01 +/- 0.08 mu M for compound 6. The biological activity of ligand and metal complexes against enzymes was compared with molecular docking method. The enzymes used against ligand and metal complexes respectively: Achethylcholinesterase for ID 4M0E (AChE), butyrylcholinesterase for ID 5NN0 (BChE), alpha-glycosidase for ID 1XSI (alpha-Gly). ADME analysis was performed to examine the drug properties of the compounds (3-6). Besides, the anticancer properties of the complexes were studied. The doses of all compounds caused significant reductions in MCF-7 cell viability. The 3 and 5 compounds administered to PC-3 cells exhibited a more pronounced cytotoxic effect than the other two compounds (4 and 6). Furthermore, antibacterial activities of these compounds against Escherichia coli and Staphylococcus aureus were examined. Communicated by Ramaswamy H. Sarma
dc.identifier.doi10.1080/07391102.2020.1844051
dc.identifier.endpage3002
dc.identifier.issn0739-1102
dc.identifier.issn1538-0254
dc.identifier.issue7
dc.identifier.pmid33234029
dc.identifier.scopus2-s2.0-85096561911
dc.identifier.scopusqualityQ2
dc.identifier.startpage2991
dc.identifier.urihttps://doi.org/10.1080/07391102.2020.1844051
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30484
dc.identifier.volume40
dc.identifier.wosWOS:000592039800001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Biomolecular Structure & Dynamics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPhthalocyanines
dc.subjectanticancer
dc.subjectenzyme inhibition
dc.subjectmolecular docking
dc.titleMetal contained Phthalocyanines with 3,4-Dimethoxyphenethoxy substituents: their anticancer, antibacterial activities and their inhibitory effects on some metabolic enzymes with molecular docking studies
dc.typeArticle

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