Evaluation of hepatoprotective and antidiabetic activity of Alchemilla mollis

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dc.authoridkeskin, ilknur -- 0000-0002-7059-1884; Ozbek, Hanefi -- 0000-0002-8084-7855; OZBILGIN, Serkan -- 0000-0002-3945-6756; SALTAN, HAYRIYE GULCIN -- 0000-0001-6633-0713; Tekin, Mehmet -- 0000-0002-6504-2223en_US
dc.contributor.authorOzbek, Hanefi
dc.contributor.authorAcikara, Ozlem Bahadir
dc.contributor.authorKeskin, Ilknur
dc.contributor.authorKirmizi, Neriman Ipek
dc.contributor.authorOzbilgin, Serkan
dc.contributor.authorOz, Burcin Ergene
dc.contributor.authorKurtul, Ekin
dc.contributor.authorOzrenk, Bade Cevriye
dc.contributor.authorTekin, Mehmet
dc.contributor.authorSaltan, Gulcin
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:44:01Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:44:01Z
dc.date.issued2017
dc.department[Ozbek, Hanefi] Istanbul Medipol Univ, Dept Pharmacol, Fac Med, Istanbul, Turkey -- [Acikara, Ozlem Bahadir -- Ozbilgin, Serkan -- Oz, Burcin Ergene -- Kurtul, Ekin -- Saltan, Gulcin] Ankara Univ, Dept Pharmacognosy, Fac Pharm, Ankara, Turkey -- [Keskin, Ilknur] Istanbul Medipol Univ, Dept Histol & Embryol, Fac Med, Istanbul, Turkey -- [Kirmizi, Neriman Ipek -- Ozrenk, Bade Cevriye] Istanbul Medipol Univ, Fac Med, Dept Vocat, Sch Hlth Serv, Istanbul, Turkey -- [Tekin, Mehmet] Cumhuriyet Univ, Dept Pharmaceut Bot, Fac Pharm, Sivas, Turkeyen_US
dc.description.abstractAlchemilla mollis (Buser) Rothm aerial part and root methanolic-water extracts were evaluated for their hepatoprotective activity on carbon tetrachloride induced hepatotoxicity and hypoglycemic activity on alloxan-induced diabetic mice. None of the tested extracts exhibited effects on blood glucose levels. However hepatoprotective activity results have revealed that serum ALT levels were significantly lowered by both the aerial part and root extracts at doses of 100 mg/kg and 200 mg/kg. Histopathological examination showed that A. mollis aerial parts and roots induced significant recovery from cellular damage; when compared to the carbon tetrachloride group, the most significant activity was observed with A. mollis aerial part extracts at a dose of 200 mg/kg. There is evidence of a hepatoprotective activity of A. mollis on the phenolic content of the plant, especially in the case of flavonoids, which have potent antioxidant properties. (C) 2016 Elsevier Masson SAS. All rights reserved.en_US
dc.identifier.doi10.1016/j.biopha.2016.12.005en_US
dc.identifier.endpage176en_US
dc.identifier.issn0753-3322
dc.identifier.issn1950-6007
dc.identifier.pmid27978496en_US
dc.identifier.scopus2-s2.0-85004009829en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage172en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.biopha.2016.12.005
dc.identifier.urihttps://hdl.handle.net/20.500.12418/6864
dc.identifier.volume86en_US
dc.identifier.wosWOS:000395523800024en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIERen_US
dc.relation.ispartofBIOMEDICINE & PHARMACOTHERAPYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlchemilla mollisen_US
dc.subjectHepatoprotective activityen_US
dc.subjectAntidiabetic activityen_US
dc.subjectMiceen_US
dc.subjectRatsen_US
dc.titleEvaluation of hepatoprotective and antidiabetic activity of Alchemilla mollisen_US
dc.typeArticleen_US

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