Determination of PD-1 expression in peripheral blood cells in patients with endometriosis

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dc.authoridhepokur, ceylan/0000-0001-6397-1291
dc.contributor.authorOksasoglu, Bugra
dc.contributor.authorHepokur, Ceylan
dc.contributor.authorMisir, Sema
dc.contributor.authorYildiz, Caglar
dc.contributor.authorSonmez, Gamze
dc.contributor.authorYanik, Ali
dc.date.accessioned2024-10-26T18:03:51Z
dc.date.available2024-10-26T18:03:51Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractIn patients with endometriosis, ectopic endometrial tissues can escape from immune system control and survive in other tissues. The pathophysiology of endometriosis is still not fully understood. In this study, we aimed to clarify the pathophysiology of endometriosis, which is thought to be a benign but infiltrative cancer type, which has many similarities with cancer biology by determining PD-1 expression in patients with endometriosis. In this study, n = 73 cases who underwent surgery or examination at the Obstetrics and Gynecology Clinic of Sivas Cumhuriyet University Faculty of Medicine and diagnosed as endometriosis in the biopsy material taken with the pre-diagnosis of endometriosis constituted the patient group. The control group consisted of n = 64 healthy subjects without concomitant malignancy or chronic inflammatory disease. Venous whole blood samples were obtained from the study groups. PD-1 and PD-L1 levels were determined by the ELISA method from serum and plasma samples. PD-1 gene expression level was determined by RT-PCR. The PD-1 level was found to be approximately 350 +/- 150 ng/L and 45 +/- 17 ng/L in endometriosis and control group, respectively. While the PD-L1 level was approximately 760 +/- 108 ng/L in the patients, this level was 140 +/- 14 ng/L in the controls. According to the RT-PCR results, the expression of the PD-1 gene 10 times higher compared to the controls. Conclusion: The identified increase of PD-1 levels and gene expression in endometriosis groups show that immunotherapy may be used in the treatment of endometriosis.
dc.description.sponsorshipCUBAP project [T-779]
dc.description.sponsorshipThis study was supported by CUBAP project no. T-779.
dc.identifier.doi10.1080/09513590.2020.1821358
dc.identifier.endpage161
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue2
dc.identifier.pmid33078970
dc.identifier.scopus2-s2.0-85093527692
dc.identifier.scopusqualityQ2
dc.identifier.startpage157
dc.identifier.urihttps://doi.org/10.1080/09513590.2020.1821358
dc.identifier.urihttps://hdl.handle.net/20.500.12418/28620
dc.identifier.volume37
dc.identifier.wosWOS:000583338900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofGynecological Endocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEndometriosis
dc.subjectPD-1
dc.subjectimmunotherapy
dc.titleDetermination of PD-1 expression in peripheral blood cells in patients with endometriosis
dc.typeArticle

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