Drug Adherence in Patients With Nonvalvular Atrial Fibrillation Taking Non-Vitamin K Antagonist Oral Anticoagulants in Turkey: NOAC-TR

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dc.contributor.authorEmren, Sadik Volkan
dc.contributor.authorSenoz, Oktay
dc.contributor.authorBilgin, Murat
dc.contributor.authorBeton, Osman
dc.contributor.authorAslan, Abdullah
dc.contributor.authorTaskin, Ugur
dc.contributor.authorAciksari, Gonul
dc.contributor.authorAsarcikli, Lale Dinc
dc.contributor.authorCakir, Hakan
dc.contributor.authorBekar, Lutfu
dc.contributor.authorBolat, Ismail
dc.contributor.authorYayla, Cagri
dc.contributor.authorCelebi, Baris
dc.contributor.authorDalgic, Onur
dc.contributor.authorCelik, Oguzhan
dc.contributor.authorSafak, Ozgen
dc.contributor.authorAkyel, Serdar
dc.contributor.authorGungor, Hasan
dc.contributor.authorDuzel, Baris
dc.contributor.authorZoghi, Mehdi
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:38:17Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:38:17Z
dc.date.issued2018
dc.department[Emren, Sadik Volkan] Afyonkarahisar State Hosp, Dept Cardiol, TR-03000 Afyon, Turkey -- [Senoz, Oktay] Artvin State Hosp, Dept Cardiol, Artvin, Turkey -- [Bilgin, Murat -- Asarcikli, Lale Dinc] Ankara Diskapi Res & Educ Hosp, Dept Cardiol, Ankara, Turkey -- [Beton, Osman] Sivas Cumhuriyet Univ, Dept Cardiol, Sivas, Turkey -- [Aslan, Abdullah] Dokuz Eylul Univ, Dept Cardiol, Izmir, Turkey -- [Taskin, Ugur] Aksehir State Hosp, Dept Cardiol, Konya, Turkey -- [Aciksari, Gonul] Istanbul Istinye State Hosp, Dept Cardiol, Istanbul, Turkey -- [Cakir, Hakan] Darica Farabi State Hosp, Dept Cardiol, Kocaeli, Turkey -- [Bekar, Lutfu] Hitit Univ, Dept Cardiol, Corum, Turkey -- [Bolat, Ismail] Fethiye State Hosp, Dept Cardiol, Mugla, Turkey -- [Yayla, Cagri] Ankara Yuksek Ihtisas Res & Educ Hosp, Dept Cardiol, Ankara, Turkey -- [Celebi, Baris] Silifke State Hosp, Dept Cardiol, Mersin, Turkey -- [Dalgic, Onur] Karsiyaka State Hosp, Dept Cardiol, Izmir, Turkey -- [Celik, Oguzhan] Hitit Univ, Sch Med, Dept Cardiol, Corum, Turkey -- [Safak, Ozgen] Burdur State Hosp, Dept Cardiol, Burdur, Turkey -- [Akyel, Serdar] Munif Islamoglu State Hosp, Dept Cardiol, Kastamonu, Turkey -- [Gungor, Hasan] Aydin Univ, Sch Med, Dept Cardiol, Aydin, Turkey -- [Duzel, Baris] Mersin State Hosp, Dept Cardiol, Mersin, Turkey -- [Zoghi, Mehdi] Ege Univ, Dept Cardiol, Izmir, Turkeyen_US
dc.description.abstractAdherence to non-vitamin K antagonist oral anticoagulants (NOACs) is an important factor for ensuring efficacy and safety in nonvalvular atrial fibrillation (NVAF). There are controversial results regarding NOAC adherence in real-world data and there are no data about NOAC adherence in Turkish population. This study investigated the NOAC adherence based on self-report, factors affecting nonadherence, and the relation of the adherence level with efficacy and safety outcomes. This multicenter cross-sectional study included 2738 patients (59% female) using NOAC (dabigatran, apixaban, and rivaroxaban) due to NVAF for more than 3 months with >30 days of supply between September 1, 2015, and February 28, 2016. To measure the adherence level, an 8-item Morisky Medication Adherence Scale was used. The mean age of the patients was 70 +/- 10 years. Of the 2738 patients, 44% were receiving dabigatran, 38% rivaroxaban, and 18% apixaban. A total of 630 (23%) patients had high medication adherence, 712 (26%) moderate adherence, and 1396 (51%) low adherence. Nonadherence had related to stroke (5.6% vs 2.5%, P < .001) and minor (21.2% vs 11.1%, P < .001) and major (6.1% vs 3.7%, P = .004) bleeding rates. The adherence to NOAC was found to be quite low in Turkey. Nonadherence is associated with bleeding and thromboembolic cardiovascular events. Age, taking NOAC twice a day, and the additional noncardiac diseases, depression, and dementia were the independent factors affecting poor medication adherence.en_US
dc.identifier.doi10.1177/1076029617693940en_US
dc.identifier.endpage531en_US
dc.identifier.issn1076-0296
dc.identifier.issn1938-2723
dc.identifier.issue3en_US
dc.identifier.pmid28301907en_US
dc.identifier.scopus2-s2.0-85028679201en_US
dc.identifier.scopusqualityQ2
dc.identifier.startpage525en_US
dc.identifier.urihttps://dx.doi.org/10.1177/1076029617693940
dc.identifier.urihttps://hdl.handle.net/20.500.12418/6307
dc.identifier.volume24en_US
dc.identifier.wosWOS:000429775000020en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS INCen_US
dc.relation.ispartofCLINICAL AND APPLIED THROMBOSIS-HEMOSTASISen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbleedingen_US
dc.subjectmedication adherenceen_US
dc.subjectnon-vitamin K antagonistsen_US
dc.subjectself-reporten_US
dc.titleDrug Adherence in Patients With Nonvalvular Atrial Fibrillation Taking Non-Vitamin K Antagonist Oral Anticoagulants in Turkey: NOAC-TRen_US
dc.typeArticleen_US

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