Vitamin B12-loaded chitosan-based nanoparticle-embedded polymeric nanofibers for sublingual and transdermal applications: Two alternative application routes for vitamin B12

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dc.authoridAYDIN, Saliha/0000-0001-7499-1028
dc.contributor.authorGuler, Ece
dc.contributor.authorYekeler, Humeyra Betul
dc.contributor.authorParviz, Gita
dc.contributor.authorAydin, Saliha
dc.contributor.authorAsghar, Asima
dc.contributor.authorDogan, Murat
dc.contributor.authorIkram, Fakhera
dc.date.accessioned2024-10-26T18:11:24Z
dc.date.available2024-10-26T18:11:24Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractAlzheimer's disease (AD) is a neurodegeneration type that is biologically recognizable via beta-amyloid plaques and tau neurofibril tangles. Global estimation for the total count of individuals enduring AD will rise up to 131 million by 2050. Investigations suggested the existence of a direct proportion between the likelihood of AD occurrence and vitamin B12 (VB12) hypovitaminosis. Approved VB12 administrations, intramuscular and oral, each has serious defects broaching the demand for alternative routes. This work developed VB12-loaded chitosan/tripolyphosphate/polyvinyl alcohol (CS/TPP/PVA) nanoparticles (NPs) embedded in polyvinylpyrrolidone (PVP) and polyvinylpyrrolidone/polycaprolactone (PVP/PCL) nanofibrous (NFs) produced by pressurized gyration (PG) for sublingual and transdermal routes, respectively. Biomaterials were investigated morphologically, chemically, and thermally. Moreover, degradation, disintegration, release behavior, and release kinetics were analyzed. The effectiveness and safety of nanomaterials were assessed and proven with the alamarBlue test on the A beta 1-42-induced SH-SY5Y model. The final evaluation suggested the feasibility, safety, and effectiveness of produced systems. Consequently, two alternative VB12 application routes were developed with high effectivity and low toxicity with the power of nanotechnology.
dc.description.sponsorshipTUSEB A1 Research Projects Program Grant [27900]; Council of Higher Education [TUBITAK 2211-A, TUBITAK 2214-A, TUBITAK 2250]; Erasmus+ KA107 project
dc.description.sponsorshipThis project was supported by a TUSEB A1 Research Projects Program Grant (No: 27900) . E.G. acknowledges the Council of Higher Education, TUBITAK 2211-A, TUBITAK 2214-A, and TUBITAK 2250 for her scholarships. E.G and M.E.C. acknowledges Erasmus+ KA107 project for funding their visit to COMSATS University Islamabad, Lahore Campus, Pakistan. E.G., H.B.Y., and M.E.C. acknowledges Division of Surgery and Interventional Sciences, University College London, UK, for hosting them in their department. The authors dedicate this article to the memory of Turkish citizens, who lost their lives in the earthquakes held in Pazarc & imath;k and Elbistan, Kahramanmaras,, Tuerkiye on February 06, 2023.
dc.identifier.doi10.1016/j.ijbiomac.2023.128635
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid38065445
dc.identifier.scopus2-s2.0-85181766493
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2023.128635
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30659
dc.identifier.volume258
dc.identifier.wosWOS:001153178200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAlzheimer 's disease
dc.subjectVitamin B 12
dc.subjectDrug delivery
dc.titleVitamin B12-loaded chitosan-based nanoparticle-embedded polymeric nanofibers for sublingual and transdermal applications: Two alternative application routes for vitamin B12
dc.typeArticle

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