Increased nociceptive sensitivity is associated with periodontal inflammation and expression of chronic pain genes in gingival tissues of male rats

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dc.authoridozkaraca, mustafa/0000-0002-6359-6249
dc.authoridtoraman, emine/0000-0001-7732-6189
dc.contributor.authorToraman, Ayse
dc.contributor.authorToraman, Emine
dc.contributor.authorOzkaraca, Mustafa
dc.contributor.authorBudak, Harun
dc.date.accessioned2024-10-26T18:06:02Z
dc.date.available2024-10-26T18:06:02Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: This study aimed to evaluate the inflammatory response, hyperpolarization-activated cyclic nucleotide-gated 2 (HCN2), and voltage-gated potassium (Kv) 9.1 channel expression in rats with paclitaxel-induced neuropathic pain-like behavior. Methods: Sixteen male Sprague Dawley rats were divided equally into two groups: control and paclitaxel-induced pain (PTX). The attachment loss and inflammatory cell infiltrate levels were analyzed histometrically and immunohistochemically. The gene expression of HCN2 and KCNS1 was analyzed by qPCR in the brain and gingival tissues. Results: The attachment loss and prominent infiltration of inflammatory cells were significantly higher in the PTX group than in the control groups. In gingival tissues; the expression levels of HCN2 (p = 0,0011) were significantly higher and KCNS1 (p = 0,0003) were significantly lower in the PTX group than in the control groups. Conclusion: Increased nociceptive sensitivity, may play a role in periodontal inflammation. KCNS1 may decrease and HCN2 expression may increase in periodontium in permanent chronic pain states. The results of the present study may be helpful in developing new approaches to alleviate pain and maintain periodontal health in patients suffering from orofacial pain.
dc.identifier.doi10.1016/j.cbi.2022.110128
dc.identifier.issn0009-2797
dc.identifier.issn1872-7786
dc.identifier.pmid36029805
dc.identifier.scopus2-s2.0-85137298736
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.cbi.2022.110128
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29327
dc.identifier.volume366
dc.identifier.wosWOS:000861651900005
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.relation.ispartofChemico-Biological Interactions
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPeriodontal disease
dc.subjectHCN channel
dc.subjectKcns1
dc.subjectChronic pain
dc.subjectNociceptive sensitivity
dc.titleIncreased nociceptive sensitivity is associated with periodontal inflammation and expression of chronic pain genes in gingival tissues of male rats
dc.typeArticle

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