Natural ingredients included antimicrobial lozenge formulations for oral care

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dc.authoridDosler, sibel/0000-0001-5223-4755
dc.contributor.authorEsentuerk-guezel, Imren
dc.contributor.authorAbdo, Lueceyn
dc.contributor.authorTopuzoglu, Sehernaz
dc.contributor.authorYildiz, Cenk
dc.contributor.authorYilmaz, Fatima Nur
dc.contributor.authorDosler, Sibel
dc.date.accessioned2024-10-26T18:08:07Z
dc.date.available2024-10-26T18:08:07Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractLozenges are easy -to -use solid/semi-solid dosage forms that can contain one or more active ingredients, which can be used in the local treatment of mouth and throat infections. Honey, propolis, and perga, which are bee hive natural products have properties of antimicrobial and nutrient. While the oil of seaweed has a rich omega -3 content, the essential oils of pine turpentine, juniper, eucalyptus, sage, lemon balm, and tea tree have antimicrobial properties. In this study, it is aimed to prepare the above indicated ingredients included antimicrobial lozenges. Prepared formulations were evaluated by characterization and antimicrobial efficiency tests. Characterization tests included the determination of organoleptic parameters, weight variation, friability, and in vitro disintegration time. Antimicrobial efficacy was determined with the antimicrobial activities of lozenges against group A 13 -hemolytic streptococci, group B 13 -hemolytic streptococci, Staphylococcus aureus, Klebsiella pneumoniae, and Candida albicans which was evaluated by broth microdilution and time -kill studies. Results showed that all the formulations showed acceptable characterization profiles and antimicrobial efficiency. The lozenge formulation, which included honey, propolis, Perga, seaweed oil, and essential oils of pine turpentine, juniper, and eucalyptus can be accepted as the best formulation in terms of antimicrobial activities against all of the tested microorganisms especially Group A beta -hemolytic streptococci which is the most frequent bacterial pathogen causing sore throat in the oral cavity. In conclusion, natural ingredients included lozenges can be a good alternative for oral care products with their good antimicrobial properties for a wide range of populations.
dc.identifier.doi10.29228/jrp.692
dc.identifier.endpage257
dc.identifier.issn2630-6344
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85185449015
dc.identifier.scopusqualityQ3
dc.identifier.startpage248
dc.identifier.urihttps://doi.org/10.29228/jrp.692
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29817
dc.identifier.volume28
dc.identifier.wosWOS:001167297700023
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherMarmara Univ
dc.relation.ispartofJournal of Research in Pharmacy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHoneybee products
dc.subjectessential oils
dc.subjectlozenge
dc.subjectoral care
dc.titleNatural ingredients included antimicrobial lozenge formulations for oral care
dc.typeArticle

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