Notch signaling and MicroRNA: The dynamic duo steering between neurogenesis and glioblastomas

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dc.authoridSharifi-Rad, Javad/0000-0002-7301-8151
dc.authoridBazzoni, Riccardo/0000-0002-5977-7178
dc.authoridBentivegna, Angela/0000-0001-7535-846X
dc.authoridKhan, Khushbukhat/0000-0002-9946-9057
dc.contributor.authorJaved, Zeeshan
dc.contributor.authorKhan, Khushbukhat
dc.contributor.authorRaza, Qamar
dc.contributor.authorSadia, Haleema
dc.contributor.authorShah, Faiez Ahmad
dc.contributor.authorAhmad, Touqeer
dc.contributor.authorBentivegna, Angela
dc.date.accessioned2024-10-26T18:11:36Z
dc.date.available2024-10-26T18:11:36Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractNotch signaling is an evolutionary conserved pathway that plays a central role in development and differentiation of eukaryotic cells. It has been well documented that Notch signaling is inevitable for neuronal cell growth and homeostasis. It regulates processes of differentiation from early embryonic stages to fully developed brain. To achieve this streamlined development of neuronal cells, a number of cellular processes are orchestrated by Notch signaling. Abrogated Notch signaling is related to several brain tumors, including glioblastomas. On the other hand, microRNAs are small molecules that play decisive roles in mediating and modulating Notch signaling. This review discusses the crucial role of Notch signaling in the development of the nervous system and how this versatile pathway interplays with microRNAs in glioblastoma. This review sheds light on the interplay between abrogated Notch signaling and miRNAs in the regulation of neuronal differentiation with special focus on miRNAs-mediated regulation of tumorigenesis in glioblastoma. Furthermore, it discusses different aspects of neurogenesis modulated by Notch signaling that could be exploited for the identification of new diagnostic tools and therapies for the treatment of glioblastoma.
dc.identifier.doi10.14715/cmb/2021.67.2.6
dc.identifier.endpage43
dc.identifier.issn0145-5680
dc.identifier.issn1165-158X
dc.identifier.issue2
dc.identifier.pmid34817376
dc.identifier.scopus2-s2.0-85116791361
dc.identifier.scopusqualityQ4
dc.identifier.startpage33
dc.identifier.urihttps://doi.org/10.14715/cmb/2021.67.2.6
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30757
dc.identifier.volume67
dc.identifier.wosWOS:000744172400006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherC M B Assoc
dc.relation.ispartofCellular and Molecular Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNotch signaling
dc.subjectmiRNAs
dc.subjectGlioblastoma
dc.subjectTumorigenesis
dc.subjectTherapeutics
dc.titleNotch signaling and MicroRNA: The dynamic duo steering between neurogenesis and glioblastomas
dc.typeReview Article

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