The effect of smoking and electronic cigarettes on rat testicles

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dc.authoridSaygin, Hasan/0000-0003-2479-7635
dc.contributor.authorSaygin, Huseyin
dc.contributor.authorKorgali, Esat
dc.contributor.authorKoc, Tulay
dc.contributor.authorDogan, Kubra
dc.date.accessioned2024-10-26T18:07:26Z
dc.date.available2024-10-26T18:07:26Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: After the negative effects of smoking on public health were proven, smoking cessation campaigns were initiated by health ministries and non-governmental organizations. Many drugs have been tried to reduce the addiction to smoking and the nicotine contained in it. Recently, e-cigarettes (EC) are widely used for smoking cessation efforts, although the effects and possible harms are not fully known. In our study, we planned to show the effect of cigarette and EC smoke on the male urogenital system. Methods: Adult male wistar rats were exposed to cigarette and EC smoke in a specially designed glass bell jar. Urine cotinine levels, testicular weights, gonadosomatic index, sperm count and sperm motility, testicular histology, and biochemical findings were compared with the control group. Results: In some rats in the cigarette and EC group, the seminiferous tubules were disorganized, and the germ cells and Sertoli cells were separated and shed. Stopped germ cell separation, cavity formation, necrosis, fibrosis, and atrophy were observed in severe cases. Higher PCO levels were found in the cigarette group compared to controls. Tissue homogenates levels of LPO were higher in both EC and cigarette groups compared to controls. No significant differences were observed between groups in terms of sperm motility and sperm count. Conclusion: Cigarette and EC liquid can increase oxidative stress as well as cause morphological changes in the testicle. To be a safe option in smoking cessation studies, its effect on people needs to be enlightened. (c) 2023 Asociacion Espanola de Androlog ' ia, Medicina Sexual y Reproductiva. Published by Elsevier Espana, S.L.U. All rights reserved.
dc.identifier.doi10.1016/j.androl.2023.100365
dc.identifier.issn1698-031X
dc.identifier.issue3
dc.identifier.pmid37276739
dc.identifier.scopus2-s2.0-85163508152
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1016/j.androl.2023.100365
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29498
dc.identifier.volume21
dc.identifier.wosWOS:001016448300001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Espana Slu
dc.relation.ispartofRevista Internacional De Andrologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectElectronic cigarette
dc.subjectCigarette
dc.subjectOxidative stress
dc.subjectSperm parameters
dc.titleThe effect of smoking and electronic cigarettes on rat testicles
dc.typeArticle

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