Is it possible to use Proton Pump Inhibitors in COVID-19 treatment and prophylaxis?

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dc.contributor.authorTastemur, Seyma
dc.contributor.authorAtaseven, Hilmi
dc.date.accessioned2024-10-26T18:08:05Z
dc.date.available2024-10-26T18:08:05Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractCoronaviruses (CoV), discovered after 1960, caused human life-threatening outbreaks. SARS-CoV2, which appeared in Wuhan, China in December 2019, causing Severe Acute Respiratory Syndrome and has different features than other coronaviruses, has been determined and the disease caused by the virus has been called Coronavirus Disease-2019 (COVID-19). This disease activates both the natural and acquired immune system. The cytokin storm, in which blood levels of proinflammatory cytokines are detected excessively high is developing and the uncontrolled inflammatory response causes local and systemic tissue damages. Although a spesific drug has not been found yet, the medications currently in use for other indications, whose pharmacokineticpharmacodynamic properties and toxic doses are already known; are included in the treatment practice of COVID-19. These drugs affect the entry of the virus into the cell and its intracellular distribution. They also have anti-inflammatory and immunomodulating effects too. Therefore, we think that Proton Pump Inhibitors (PPI's) with similar mechanisms of action may also be involved in COVID-19 treatment and prophylaxis.
dc.identifier.doi10.1016/j.mehy.2020.110018
dc.identifier.issn0306-9877
dc.identifier.issn1532-2777
dc.identifier.pmid32679422
dc.identifier.scopus2-s2.0-85087882685
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.mehy.2020.110018
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29791
dc.identifier.volume143
dc.identifier.wosWOS:000577511800067
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofMedical Hypotheses
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCOVID-19
dc.subjectSARS-CoV2
dc.subjectProton Pump Inhibitors
dc.subjectTreatment
dc.titleIs it possible to use Proton Pump Inhibitors in COVID-19 treatment and prophylaxis?
dc.typeArticle

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