The effects of repeated doses of xylazine-ketamine and medetomidine- ketamine anesthesia on DNA damage in the liver and kidney

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dc.contributor.authorSancak, Tunahan
dc.date.accessioned2024-10-26T18:02:11Z
dc.date.available2024-10-26T18:02:11Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractPurpose: This study evaluated the DNA damage caused by repeated doses of xylazine-ketamine and medetomidine-ketamine anesthesia in the liver and kidneys.Methods: In this study, 60 rats were used. The rats were divided into group 1 (xylazine-ketamine), and group 2 (medetomidine-ketamine), and these anesthetic combinations were administered to the rats at repeated doses with 30-min intervals. The effects of these anesthetic agents on the tumor necrosis factor-alpha gene for DNA damage were investigated.Results: According to the gene expression results, it was observed that a single dose of xylazine-ketamine was 2.9-fold expressed, while first and second repeat doses did not show significant changes in expression levels. However, in the case of the third repetition, it was observed to be 3.8-fold overexpressed. In the case of medetomidine-ketamine administration, it was observed that a single-dose application resulted in a 1.04-fold expression, while the first and the third repeat doses showed a significant down expression. The samples from the second repeat dose administration group were found to have insignificant levels of expression.Conclusion: This study can contribute to understanding the safe anesthetic combination in research and operations in which xylazine-ketamine and medetomidine-ketamine combinations are used.
dc.identifier.doi10.1590/acb385723
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.pmid37909595
dc.identifier.scopus2-s2.0-85175546828
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.1590/acb385723
dc.identifier.urihttps://hdl.handle.net/20.500.12418/27983
dc.identifier.volume38
dc.identifier.wosWOS:001096086400001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherActa Cirurgica Brasileira
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnesthesia
dc.subjectDNA Damage
dc.subjectGene Expression
dc.subjectRepeated Dose
dc.subjectTumor Necrosis Factor-alpha
dc.titleThe effects of repeated doses of xylazine-ketamine and medetomidine- ketamine anesthesia on DNA damage in the liver and kidney
dc.typeArticle

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