Effect of Isotretinoin Treatment on the Inflammatory Markers in Patients with Acne Vulgaris: A Case-Control Study

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dc.contributor.authorDi?iş, Mahir
dc.contributor.authorTosun, Mustafa
dc.contributor.authorYasak Güner, Rukiye
dc.contributor.authorAkyol, Melih
dc.date.accessioned2024-10-26T17:51:28Z
dc.date.available2024-10-26T17:51:28Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: Oral isotretinoin can affect inflammation markers in patients with acne vulgaris. This study aims to examine the impact of isotretinoin treatment on inflammatory markers in patients diagnosed with acne vulgaris. Material and Methods: Fifty-five patients diagnosed with moderate or severe acne vulgaris according to the Global Acne Grading Scale were included in this study. Patients were evaluated at regular intervals (at 0, 2nd, and 3rd months) during the treatment period. Complete blood count [including mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), plateletcrit, platelet distribution width (PDW), platelet-to-lymphocyte ratio (PLR), red cell distribution width (RDW)], Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), Aggregate Index of Systemic Inflammation (AISI), monocyte-high-density lipoprotein (HDL) ratio, monocyte-to-lymphocyte ratio (MLR), MPV/platelet ratio, and serum biochemistry panel were assessed during isotretinoin treatment. Additionally, the Acne Quality of Life Scale was used to assess patients' quality of life. Results: A significant increase in PLR and RDW levels was observed during isotretinoin treatment (p<0.05). However, SII, SIRI, AISI, monocyte/HDL ratio, NLR, PDW, MPV, sedimentation rate, and C-reactive protein levels did not show a significant change during isotretinoin treatment (p>0.05). Furthermore, this study demonstrated that oral isotretinoin treatment reduced the severity of acne and improved patients' quality of life. Conclusion: Isotretinoin may have inflammatory effects shown with PLR and RDW. However, other inflammatory markers did not show a significant change during isotretinoin treatment. Further comprehensive studies are needed to better understand the relationship between isotretinoin treatment and inflammatory markers. Copyright © 2024 by Türkiye Klinikleri.
dc.identifier.doi10.5336/dermato.2023-97752
dc.identifier.endpage7
dc.identifier.issn1300-0330
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85192361725
dc.identifier.scopusqualityQ4
dc.identifier.startpage1
dc.identifier.trdizinid1238541
dc.identifier.urihttps://doi.org/10.5336/dermato.2023-97752
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1238541
dc.identifier.urihttps://hdl.handle.net/20.500.12418/26249
dc.identifier.volume34
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherOrtadogŸu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S.
dc.relation.ispartofTurkiye Klinikleri Dermatoloji
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectacne vulgaris; inflammatory markers; Isotretinoin
dc.titleEffect of Isotretinoin Treatment on the Inflammatory Markers in Patients with Acne Vulgaris: A Case-Control Study
dc.title.alternativeIzotretinoin Tedavisinin Akne Vulgarisli Hastalarda Inflamatuar Belirteçler Üzerine Etkisi: Bir Olgu Kontrol Çalişmasi
dc.typeArticle

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