The prognostic value of UHRF-1 and p53 in gastric cancer

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dc.contributor.authorBabacan, Nalan A.
dc.contributor.authorEgilmez, Hatice Reyhan
dc.contributor.authorYucel, Birsen
dc.contributor.authorParlak, Ilknur
dc.contributor.authorSeker, Mehmet Metin
dc.contributor.authorKacan, Turgut
dc.contributor.authorBahceci, Aykut
dc.contributor.authorCihan, Sener
dc.contributor.authorAkinci, Bulent
dc.contributor.authorEriten, Berna
dc.contributor.authorKilickap, Saadettin
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T09:46:55Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T09:46:55Z
dc.date.issued2016
dc.department[Babacan, Nalan A. -- Seker, Mehmet Metin -- Kacan, Turgut -- Bahceci, Aykut] Cumhuriyet Univ, Sch Med, Dept Med Oncol, Sivas, Turkey -- [Egilmez, Hatice Reyhan -- Eriten, Berna] Cumhuriyet Univ, Sch Med, Dept Pathol, Sivas, Turkey -- [Yucel, Birsen] Cumhuriyet Univ, Sch Med, Dept Radiat Oncol, Sivas, Turkey -- [Parlak, Ilknur] Cumhuriyet Univ, Sch Med, Dept Internal Med, Sivas, Turkey -- [Cihan, Sener] Okmeydani Educ & Res Hosp, Dept Med Oncol, Istanbul, Turkey -- [Akinci, Bulent] Yildirim Beyazit Univ, Sch Med, Dept Med Oncol, Ankara, Turkey -- [Kilickap, Saadettin] Hacettepe Univ, Sch Med, Dept Med Oncol, Ankara, Turkeyen_US
dc.description.abstractBackground/Aims: This study aimed to examine whether UHRF-1 and p53 overexpression is a prognostic marker for gastric cancer. Patients and Methods: Sixty-four patients with gastric cancer (study group) and 23 patients with gastritis (control group) were evaluated. Immunohistochemistry was used to examine expression of UHRF-1 and p53 in gastric cancers and a control group diagnosed with gastritis. Results: The median age was 63 years (18-83 years) in the study group. UHRF-1 was positive in 15 (23%) patients with gastric cancer and fi ve (21.7%) patients with gastritis (P = 0.559). UHRF1 expression level in gastric cancer is more powerful than in gastritis (P = 0.046). Thirty-seven (61%) patients with gastric cancer and only one patient with gastritis were p53 positive (P < 0.001). After a median follow-up of 12 months (1-110), the 2-year overall survival rates were 55% and 30% in negative and positive p53, respectively (P = 0.084). Also, the 2-year overall survival rates were 45% and 53% in negative and positive UHRF-1, respectively (P = 0.132). Conclusion: According to this study, UHRF-1and p53 were not prognostic factors for gastric cancer, whereas they may have a diagnostic value for differantiating between gastric cancer and gastritis.en_US
dc.description.sponsorshipCumhuriyet University Scientific Research Project Unit [T-522]en_US
dc.description.sponsorshipThe work was supported by grants from Cumhuriyet University Scientific Research Project Unit (T-522), Conflict of Interest: None declared.en_US
dc.identifier.doi10.4103/1319-3767.173755en_US
dc.identifier.endpage29en_US
dc.identifier.issn1319-3767
dc.identifier.issn1998-4049
dc.identifier.issue1en_US
dc.identifier.pmid26831603en_US
dc.identifier.scopus2-s2.0-84955444457en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage25en_US
dc.identifier.urihttps://dx.doi.org/10.4103/1319-3767.173755
dc.identifier.urihttps://hdl.handle.net/20.500.12418/7595
dc.identifier.volume22en_US
dc.identifier.wosWOS:000372831800004en_US
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMEDKNOW PUBLICATIONS & MEDIA PVT LTDen_US
dc.relation.ispartofSAUDI JOURNAL OF GASTROENTEROLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGastric canceren_US
dc.subjectp53 genesen_US
dc.subjectprognosisen_US
dc.subjectsurvivalen_US
dc.subjectUHRF-1 proteinen_US
dc.titleThe prognostic value of UHRF-1 and p53 in gastric canceren_US
dc.typeArticleen_US

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