Synthesis, antimicrobial and antibiofilm activities of silver(I) complexes with N-alkylbenzimidazole derivatives and their protein interaction modelling study

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dc.authoridMerghni, Abderrahmen/0000-0003-4427-0208
dc.authoridAifa, Sami/0000-0003-1466-5890
dc.contributor.authorSahin, Neslihan
dc.contributor.authorMosrati, Mohamed Ali
dc.contributor.authorMerghni, Abderrahmen
dc.contributor.authorOzdemir, Ismail
dc.contributor.authorSellami, Hayet
dc.contributor.authorBedchiche, Kawther
dc.contributor.authorKrayiem, Salim
dc.date.accessioned2025-05-04T16:47:08Z
dc.date.available2025-05-04T16:47:08Z
dc.date.issued2025
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractThis study investigates the antimicrobial and antibiofilm potential of three silver(I) complexes derived from Nalkylbenzimidazole derivatives: bis[(Z)-1-styryl-benzimidazole]silver(I) nitrate (4), bis[(E)-1-styryl-benzimidazole]silver(I) nitrate (5), and bis(1-cinnamyl-benzimidazole)silver(I) nitrate (6). Detailed synthesis and characterization of these complexes are followed by assessments of their efficacy against Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli, and Candida albicans. Among the tested compounds, complex 6 exhibited the highest antimicrobial activity, with a minimal inhibitory concentration of 6 mu mol/L against P. aeruginosa, and significant antibiofilm activity, achieving 67.72 % inhibition at a concentration of 3 mu mol/L. These interesting findings led us to conduct a molecular docking study to understand the mechanisms of action by investigating the interactions between the silver(I) complexes and some key protein targets involved in bacterial and fungal biofilm formation, including (p)ppGpp synthetase/hydrolases, FtsZ proteins, and pyruvate kinases. This comprehensive approach, combining experimental and computational analyses derived from N-alkylbenzimidazole derivatives, particularly complex 6, which exhibits remarkable efficacy against various pathogens, reveals promising therapeutic applications of these silver(I) complexes and advances our understanding of their potential mode of action against biofilm-associated infections.
dc.identifier.doi10.1016/j.molstruc.2024.140440
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-85214557934
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2024.140440
dc.identifier.urihttps://hdl.handle.net/20.500.12418/35489
dc.identifier.volume1322
dc.identifier.wosWOS:001359195600001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Molecular Structure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250504
dc.subjectS ilver complex
dc.subjectAntibacterial
dc.subjectAntibiofilm
dc.subjectMolecular docking
dc.subjectProtein interaction model
dc.titleSynthesis, antimicrobial and antibiofilm activities of silver(I) complexes with N-alkylbenzimidazole derivatives and their protein interaction modelling study
dc.typeArticle

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