All-in-One Nanohybrids Combining Sonodynamic Photodynamic and Photothermal Therapies

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dc.authoridSozmen, Fazli/0000-0002-2780-1487
dc.contributor.authorTaydas, Dilsad
dc.contributor.authorOzler, Muhammed Emre
dc.contributor.authorErgul, Mustafa
dc.contributor.authorInan, Zeynep Deniz Sahin
dc.contributor.authorSozmen, Fazli
dc.date.accessioned2024-10-26T18:04:12Z
dc.date.available2024-10-26T18:04:12Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractA wide variety of methods are being developed to ultimately defeat cancer; while some of these strategies have shown highly positive results, there are serious obstacles to overcome to completely eradicate this disease. So, it is crucial to construct multifunctional nanostructures possessing intelligent capabilities that can be utilized to treat cancer. A possible strategy for producing these multifunctional nanostructures is to combine various cancer treatment techniques. Based on this point of view, we successfully synthesized multifunctional HCuS@Cu2S@Au-P(NIPAM-co-AAm)-PpIX nanohybrids. The peculiarities of these thermosensitive polymer-modified and protoporphyrin IX (PpIX)-loaded hollow nanohybrids are that they combine photodynamic therapy (PDT), sonodynamic therapy (SDT), and photothermal therapy (PTT) with an intelligent design. As an all-in-one nanohybrids, HCuS@Cu2S@Au-P(NIPAM-co-AAm)-PpIX nanohybrids were employed in the SDT-PDT-PTT combination therapy, which proved to have a synergistic therapeutic effect for in vitro tumor treatments against breast tumors.
dc.identifier.doi10.1021/acsami.4c09715
dc.identifier.endpage43399
dc.identifier.issn1944-8244
dc.identifier.issn1944-8252
dc.identifier.issue33
dc.identifier.pmid39136145
dc.identifier.scopus2-s2.0-85201088993
dc.identifier.scopusqualityQ1
dc.identifier.startpage43387
dc.identifier.urihttps://doi.org/10.1021/acsami.4c09715
dc.identifier.urihttps://hdl.handle.net/20.500.12418/28796
dc.identifier.volume16
dc.identifier.wosWOS:001291125600001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAmer Chemical Soc
dc.relation.ispartofAcs Applied Materials & Interfaces
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjecthollow nanohybrids
dc.subjectphotodynamic therapy
dc.subjectsonodynamictherapy
dc.subjectphotothermal therapy
dc.subjectthermosensitive polymer
dc.titleAll-in-One Nanohybrids Combining Sonodynamic Photodynamic and Photothermal Therapies
dc.typeArticle

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