Research on Hotair and 7SL-RNA Gene Expression Levels in Psoriasis Vulgaris

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dc.authoridBayyurt, Burcu/0000-0002-5618-457X
dc.contributor.authorYazici, Seyma
dc.contributor.authorGuner, Rukiye Yasak
dc.contributor.authorAkyol, Melih
dc.contributor.authorBayyurt, Elif Burcu Tuzemen
dc.contributor.authorArslan, Serdal
dc.date.accessioned2024-10-26T18:03:51Z
dc.date.available2024-10-26T18:03:51Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBackgrounds: Mutation of protein-coding genes and non-coding genes is a factor in psoriasis etiology. Non-coding RNA (ncRNA), which does not have protein-coding capacity, is available in the human genome. HOTAIR (HOX Antisense Intergenic RNA) and 7SL-RNA are known as ncRNA. They may play a role in psoriasis pathogenesis. Aims: In our study, we aimed to investigate the level of HOTAIR and 7SL-RNA gene expression in the lesional and perilesional healthy skin of psoriasis patients. Methods: Total RNA isolation from the skin samples was achieved by modifying the RNeasy Mini Kit (Qiagen, Cat No: 74104) protocol. Real Time Polymerase Chain Reaction (qPCR) phase was performed in accordance with the protocol of the relevant brand (WizPure qPCR). Results: 7SL-RNA gene expression decreased in the skin with psoriatic lesions (FC: 0.01; p: 0.028), and this decrease was statistically significant. HOTAIR gene expression decreased (FC: 0.92; p: 0.218), but this decrease was not statistically significant. Conclusions: lncRNAs may play a role in the pathogenesis of psoriasis disease.
dc.identifier.doi10.4103/ijd.ijd_1125_20
dc.identifier.issn0019-5154
dc.identifier.issn1998-3611
dc.identifier.issue6
dc.identifier.pmid35283509
dc.identifier.scopus2-s2.0-85124120534
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.4103/ijd.ijd_1125_20
dc.identifier.urihttps://hdl.handle.net/20.500.12418/28618
dc.identifier.volume66
dc.identifier.wosWOS:000756586700031
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofIndian Journal of Dermatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject7SL-RNA
dc.subjectHOTAIR
dc.subjectnon-coding genes
dc.subjectpsoriasis
dc.titleResearch on Hotair and 7SL-RNA Gene Expression Levels in Psoriasis Vulgaris
dc.typeArticle

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