Novel indole hydrazide derivatives: Synthesis and their antiproliferative activities through inducing apoptosis and DNA damage

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dc.authoridAcar, Cemre/0000-0001-8965-3267
dc.authoridBAKAR ATES, FILIZ/0000-0003-2809-8946
dc.authoridErgul, Mustafa/0000-0003-4303-2996
dc.contributor.authorKilic-Kurt, Zuhal
dc.contributor.authorAcar, Cemre
dc.contributor.authorErgul, Mustafa
dc.contributor.authorBakar-Ates, Filiz
dc.contributor.authorAltuntas, Tunca G.
dc.date.accessioned2024-10-26T18:07:13Z
dc.date.available2024-10-26T18:07:13Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractA series of novel indole hydrazide derivatives was synthesized and evaluated for their anticancer activities. Compound 12 exhibited the highest antiproliferative activity against the MCF-7 cell line, with an IC50 value of 3.01 mu M. Treatment of MCF-7 cells with compound 12 led to cell cycle arrest at the G0/G1 phase and also displayed a significant annexin V binding pattern, indicating that compound 12 is effective in apoptotic cell death. The Western blot analysis showed that compound 12 increased the expression of proapoptotic Bax and decreased the levels of the antiapoptotic Bcl-2 protein. It was also observed that MCF-7 cells treated with compound 12 showed reduced levels of procaspase-3 and -9 proteins. Moreover, compound 12 treatment induced a significant DNA damage in MCF-7 cells by increasing H2AX and ATM phosphorylation.
dc.description.sponsorshipAnkara University
dc.description.sponsorshipAnkara University
dc.identifier.doi10.1002/ardp.202000059
dc.identifier.issn0365-6233
dc.identifier.issn1521-4184
dc.identifier.issue8
dc.identifier.pmid32419228
dc.identifier.scopus2-s2.0-85084732642
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/ardp.202000059
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29374
dc.identifier.volume353
dc.identifier.wosWOS:000533228100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofArchiv Der Pharmazie
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectanticancer activity
dc.subjectapoptosis
dc.subjectcell cycle
dc.subjectDNA damage
dc.subjectsynthesis
dc.titleNovel indole hydrazide derivatives: Synthesis and their antiproliferative activities through inducing apoptosis and DNA damage
dc.typeArticle

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