Altered spontaneous contractions of the ileum by anesthetic agents in rats exposed to peritonitis

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dc.authoridAltun, Ahmet -- 0000-0003-2056-8683en_US
dc.contributor.authorAydin, Cengiz
dc.contributor.authorBagcivan, Ihsan
dc.contributor.authorGursoy, Sinan
dc.contributor.authorAltun, Ahmet
dc.contributor.authorTopcu, Omer
dc.contributor.authorKoyuncu, Ayhan
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:14:22Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:14:22Z
dc.date.issued2009
dc.department[Aydin, Cengiz -- Topcu, Omer -- Koyuncu, Ayhan] Cumhuriyet Univ, Sch Med, Dept Gen Surg, TR-58140 Sivas, Turkey -- [Bagcivan, Ihsan -- Altun, Ahmet] Cumhuriyet Univ, Sch Med, Dept Pharmacol, TR-58140 Sivas, Turkey -- [Gursoy, Sinan] Cumhuriyet Univ, Sch Med, Dept Anesthesiol, TR-58140 Sivas, Turkeyen_US
dc.description.abstractAIM: To investigate in vitro effects of propofol, midazolam and dexmedetomidine, which are commonly used anaesthesic or sedatives, on spontaneous contractions of the ileum both in normal rats and those exposed to hyperdynamic peritonitis. METHODS: Spontaneous contractions of isolated ileum muscle segments from sham operated rats and those exposed to peritonitis, were studied in vitro. The amplitude and the frequency of spontaneous contractions of ileum muscle segments were studied after adding dexmetetomidine, propofol, and midazolam to the organ bath in a cumulative manner. RESULTS: Both amplitude (85.2 +/- 6.6 vs 47.4 +/- 7.1) and frequency (32.8 +/- 4.6 vs 20.2 +/- 3.9) of spontaneous contractions in ileum smooth muscle segments were decreased significantly in the peritonitis group compared to the control group (P < 0.05). Dexmedetomidine significantly increased the amplitude of spontaneous contractions (85.2 +/- 6.6 vs 152.0 +/- 5.4, P < 0.05) whereas, propofol (85.2 +/- 6.6 vs 49.6 +/- 4.8, P < 0.05) and midazolam (85.2 +/- 6.6 vs 39.2 +/- 4.5, P < 0.05) decreased it in both control and peritonitis groups. The frequency of spontaneous contractions were significantly decreased by propofol in both control (32.8 +/- 4.6 vs 18.2 +/- 3.4, P < 0.05) and peritonitis groups 20.2 +/- 3.9 vs 11.6 +/- 3.2, P < 0.05). Dexmedetomidine and midazolam did not cause significant changes in the number of spontaneous contractions in both control and the peritonitis groups (P > 0.05). CONCLUSION: Propofol, midazolam and dexmedetomidine have various in vitro effects on spontaneous contractions of the rat ileum. While dexmedetomidine augments the spontaneous contraction of the rat ileum, propofol attenuates it. However, the effects of these compounds were parallel in both control and peritonitis groups. (C) 2009 The WIG Press and Baishideng. All rights reserved.en_US
dc.identifier.doi10.3748/wjg.15.1620en_US
dc.identifier.endpage1624en_US
dc.identifier.issn1007-9327
dc.identifier.issue13en_US
dc.identifier.pmid19340905en_US
dc.identifier.scopus2-s2.0-64549089575en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage1620en_US
dc.identifier.urihttps://dx.doi.org/10.3748/wjg.15.1620
dc.identifier.urihttps://hdl.handle.net/20.500.12418/10153
dc.identifier.volume15en_US
dc.identifier.wosWOS:000265914400011en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW J G PRESSen_US
dc.relation.ispartofWORLD JOURNAL OF GASTROENTEROLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIleumen_US
dc.subjectPropofolen_US
dc.subjectMidazolamen_US
dc.subjectDexmedetomidineen_US
dc.subjectPeritonitisen_US
dc.titleAltered spontaneous contractions of the ileum by anesthetic agents in rats exposed to peritonitisen_US
dc.typeArticleen_US

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