Expression of ADAMTS 1-4-8 and placental growth factor in ovary and oviduct during pregnancy in the first trimester

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dc.authoridTufekci, Kiymet Kubra/0000-0002-4722-3813
dc.authoridTATAR, Musa/0000-0002-5707-8832
dc.authoridUslu, Sema/0000-0002-2239-7841
dc.contributor.authorTatar, Musa
dc.contributor.authorTufekci, Kiymet Kubra
dc.contributor.authorUslu, Sema
dc.contributor.authorOner, Jale
dc.date.accessioned2024-10-26T18:09:01Z
dc.date.available2024-10-26T18:09:01Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractA Disintegrin and Metalloprotease Domains with Thrombospondins Motifs (ADAMTS), proteinases responsible for the destruction of extracellular matrix structures, have essential roles in the physiological and pathological processes of the female reproductive system, which is a dynamic structure. This study aimed to evaluate the immunoreactivity of placental growth factor (PLGF) and ADAMTS' (1, -4, and -8) in the ovary and oviduct during pregnancy in the first trimester. Our findings suggest a predominant role of ADAMTS-4 and ADAMTS-8 as proteoglycan-degrading enzymes from the ADAMTS-1 in the first trimester. As an angiogenic factor, PLGF showed more immunoreactivity than ADAMTS-1 in the ovary. This study provides the first evidence that ADAMTS-4 and ADAMTS-8 are more expressed in ovarian cells and follicles at different developmental stages during the first trimester of pregnancy than ADAMTS-1. Consequently, we suggest that ADAMTSs and PLGF act together and may exert specific effects on the formation, stabilisation, and function (or a combination thereof) of the matrix surrounding and protecting the follicles.
dc.description.sponsorshipTurkiye Bilimsel ve Teknolojik Arastirma Kurumu [120O941]
dc.description.sponsorshipTurkiye Bilimsel ve Teknolojik Arastirma Kurumu, Grant/Award Number: 120O941
dc.identifier.doi10.1111/ahe.12922
dc.identifier.endpage626
dc.identifier.issn0340-2096
dc.identifier.issn1439-0264
dc.identifier.issue4
dc.identifier.pmid37014320
dc.identifier.scopus2-s2.0-85152042314
dc.identifier.scopusqualityQ2
dc.identifier.startpage619
dc.identifier.urihttps://doi.org/10.1111/ahe.12922
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29899
dc.identifier.volume52
dc.identifier.wosWOS:000964195400001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofAnatomia Histologia Embryologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectADAMTS
dc.subjectovary
dc.subjectoviduct
dc.subjectpregnancy
dc.subjectrat
dc.titleExpression of ADAMTS 1-4-8 and placental growth factor in ovary and oviduct during pregnancy in the first trimester
dc.typeArticle

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