Effects of NO/L-Arginine Pathway on Gallbladder Contractility in Bile Duct Ligated Guinea Pigs

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dc.contributor.authorSoylu, Sinan
dc.contributor.authorAydin, Cengiz
dc.contributor.authorBagcivan, Ihsan
dc.contributor.authorYildirim, Sahin
dc.contributor.authorKoyuncu, Ayhan
dc.contributor.authorTopcu, Omer
dc.contributor.authorArici, Sema
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:14:12Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:14:12Z
dc.date.issued2009
dc.department[Aydin, Cengiz] Cumhuriyet Univ, Dept Gen Surg, Fac Med, Sch Med, TR-58140 Sivas, Turkey -- [Bagcivan, Ihsan -- Yildirim, Sahin] Cumhuriyet Univ, Sch Med, Dept Pharmacol, TR-58140 Sivas, Turkey -- [Arici, Sema] Cumhuriyet Univ, Sch Med, Dept Pathol, TR-58140 Sivas, Turkeyen_US
dc.description.abstractBackground. Common bile duct ligation (CBDL) produces gallbladder distension and acute inflammation similar to that seen in human acute acalculous cholecystitis. CBDL in the guinea pig affects smooth muscle contractility. The aim of this study was to determine whether the nitric oxide-L-arginine pathway plays a role in the inflammatory process and abnormal gallbladder contractility that occur after CBDL. Materials and Methods. Contractility of gallbladder muscle from CBDL and sham-operated guinea pigs was studied in vitro. Animals were treated with saline, aminoguanidine (AG), or an aminoguanidine + L-arginine combination (AG + L-Arg) in vivo. Potassium chloride, carbachol, and electric field stimulation (EFS) were used for contracting the gallbladder muscle strips or activating intrinsic nerves. Hematoxylin and eosinstained slides of muscle strips were scored for inflammation. Results. Contraction responses to carbachol and EFS were decreased significantly in CBDL guinea pigs compared with those in the sham-operated group. AG partly reversed the smooth muscle contractile response to carbachol and EFS, but did not reduce the inflammation score. Treatment with AG + L-arg did not reverse either the contraction response or the inflammation score. Conclusions. These findings suggest that AG and AG + L-Arg treatments have no beneficial effect on inflammation in guinea pigs after CBDL, although AG significantly reversed the effect on muscle contractility (P < 0.05). This improvement was independent of inflammation and may be due to a decreased level of NO and its diminished relaxant effect. (C) 2009 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jss.2008.08.002en_US
dc.identifier.endpage76en_US
dc.identifier.issn0022-4804
dc.identifier.issn1095-8673
dc.identifier.issue1en_US
dc.identifier.pmid19394644en_US
dc.identifier.scopus2-s2.0-67349255734en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage70en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jss.2008.08.002
dc.identifier.urihttps://hdl.handle.net/20.500.12418/10105
dc.identifier.volume155en_US
dc.identifier.wosWOS:000267448500011en_US
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCEen_US
dc.relation.ispartofJOURNAL OF SURGICAL RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectaminoguanidineen_US
dc.subjectL-arginineen_US
dc.subjectgallbladder contractilityen_US
dc.subjectgallbladder inflammationen_US
dc.subjectcommon bile duct ligationen_US
dc.titleEffects of NO/L-Arginine Pathway on Gallbladder Contractility in Bile Duct Ligated Guinea Pigsen_US
dc.typeArticleen_US

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