Isofraxidin: Antioxidant, Anti-carbonic Anhydrase, Anti-cholinesterase, Anti-diabetic, and in Silico Properties

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dc.authoridTUZUN, BURAK/0000-0002-0420-2043
dc.authoridTaslimi, Parham/0000-0002-3171-0633
dc.contributor.authorDurmaz, Lokman
dc.contributor.authorGulcin, Ilhami
dc.contributor.authorTaslimi, Parham
dc.contributor.authorTuzun, Burak
dc.date.accessioned2024-10-26T18:09:33Z
dc.date.available2024-10-26T18:09:33Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractThe development of innovative pharmacological formulations for the treatment and prevention of various major diseases, including cancer, diabetes, and glaucoma, has been facilitated by some natural compounds. This study tested the inhibitory effects of isofraxidin on acetylcholinesterase, & alpha;-glycosidase, and butyrylcholinesterase enzymes, as well as human carbonic anhydrase I and II (hCA I and II) isoenzymes. Esterase activity was used to gauge Isofraxidin's ability to inhibit CA (in vitro). For the isoenzymes hCA I and hCA II, the half maximal inhibitory concentration (IC50) values of isofraxidin were determined to be 67.61 and 52.42 nM, respectively. At the same manner, inhibition constant (Ki) values were determined as 12.58 & PLUSMN;0.50 and 4.41 & PLUSMN;0.35 nM, respectively. Then, IC50 value of compound for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) were calculated as 18.50 and 10.75 nM, respectively. On the other hand, IC50 and Ki values of & alpha;-glycosidase were determined as 55.16 and 56.81 & PLUSMN;2.30 nM, respectively. Additionally, the antioxidant properties of isofraxidin were investigated using techniques like 2,2 & PRIME;-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 1,1-Diphenyl-2-picrylhydrazyl (DPPH), N,N-dimethyl-& rho;-phenylenediamine (DMPD), cupric ions (Cu2+) reducing antioxidant capacity (CUPRAC), and iron reduction procedures. Following the graphing of the antioxidant results, IC50 values were determined. As a result, the natural phenolic molecule showed strong profiles of inhibition profile. We therefore think that these findings may pave the way for novel therapeutic development for the management of some major illnesses. Several plant-based natural substances and extracts have gained attention in recent years as potential inhibitors of & alpha;-glycosidase enzyme. The activities of Isofraxidin molecule with various enzyme proteins were compared. Finally, ADME/T analysis was performed to predict the movements of Isofraxidin molecules in human metabolism. This study tested the antioxidant potential and inhibitory effects of isofraxidin on acetylcholinesterase, & alpha;-glycosidase, and butyrylcholinesterase enzymes, as well as human carbonic anhydrase I and II (hCA I and II) isoenzymes.image
dc.description.sponsorshipErzincan Binali Yildirim University BAP [FBA-2018-474]; Erzincan Binali Yildirim University, Research Fund [EBYUEBAP: FBA-2018-474]; Scientific Research Project Fund of Sivas Cumhuriyet University (CUBAP) [RGD-020]
dc.description.sponsorshipThis study was supported by the Erzincan Binali Yildirim University BAP unit with the project number FBA-2018-474. The authors, thank the Erzincan Binali Yildirim University, Research Fund (EBYUEBAP: FBA-2018-474) for financial support. The numerical calculations reported in this paper were fully/partially performed at TUBITAK ULAKBIM, High Performance and Grid Computing Center (TRUBA resources). This work was supported by the Scientific Research Project Fund of Sivas Cumhuriyet University (CUBAP) under the project number RGD-020.
dc.identifier.doi10.1002/slct.202300170
dc.identifier.issn2365-6549
dc.identifier.issue34
dc.identifier.scopus2-s2.0-85170044880
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/slct.202300170
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30167
dc.identifier.volume8
dc.identifier.wosWOS:001060451900001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofChemistryselect
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectADME/T
dc.subjectantidiabetic
dc.subjectantioxidant
dc.subjectcholinesterases
dc.subjectenzymes inhibition
dc.subjectIsofraxidin
dc.subjectmolecular docking
dc.titleIsofraxidin: Antioxidant, Anti-carbonic Anhydrase, Anti-cholinesterase, Anti-diabetic, and in Silico Properties
dc.typeArticle

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