Efficacy of contact lens storage solutions against trophozoite and cyst of Acanthamoeba castellanii strain 1BU and their cytotoxic potential on corneal cells

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dc.authoridCetin, Ali -- 0000-0002-5767-7894en_US
dc.contributor.authorPolat, Zubeyde Akin
dc.contributor.authorVural, Ayse
dc.contributor.authorCetin, Ali
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:16:15Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:16:15Z
dc.date.issued2007
dc.departmentCumhuriyet Univ, Sch Med, Dept Ophthalmol, TR-58140 Sivas, Turkey -- Cumhuriyet Univ, Sch Med, Dept Obstet & Gynecol, TR-58140 Sivas, Turkeyen_US
dc.description.abstractAcanthamoeba is a free-living amoeba causing a potentially blinding infection of the cornea. Contact lens wearers are most at risk and account for about 95% of cases. We investigated the in vitro effectiveness of 10 contact lens solutions against Acanthamoeba castellanii and their cytotoxicity on corneal cells in vitro. Contact lens solutions were evaluated for their amoebicidal activities using an inverted light microscope. To determine of their cytotoxicity on corneal cells, agar diffusion tests were performed. According to the results obtained from the tests, AVIZOR Aqua Soft Comfort and Elegances showed the best amoebicidal effect on A. castellanii trophozoites. Cysts were still viable after overnight (8 h) exposure. In the case of the cyctotoxic acitivities, All In One Light, AstekTm, SOLO-Care AquaTm, Maxima, and Horien showed no cytotoxicity on the corneal cells. ReNu MUltiplUSTm, AVIZOR Aqua Soft Comfort, Carrerav (R), and Elegance (R) showed mild cytotoxicity on the corneal cells. Plurisol.M presented moderate cytotoxicity on the corneal cells. All commercial solutions examined in this study are the lack of efficacy against A. castellanii. Improvement or development of new contact lens disinfecting systems by the manufacturers is needed to prevent Acanthamoeba keratitis.en_US
dc.identifier.doi10.1007/s00436-007-0576-xen_US
dc.identifier.endpage1001en_US
dc.identifier.issn0932-0113
dc.identifier.issue4en_US
dc.identifier.pmid17514482en_US
dc.identifier.scopus2-s2.0-34547726266en_US
dc.identifier.scopusqualityQ1
dc.identifier.startpage997en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00436-007-0576-x
dc.identifier.urihttps://hdl.handle.net/20.500.12418/10551
dc.identifier.volume101en_US
dc.identifier.wosWOS:000248849500020en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofPARASITOLOGY RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleEfficacy of contact lens storage solutions against trophozoite and cyst of Acanthamoeba castellanii strain 1BU and their cytotoxic potential on corneal cellsen_US
dc.typeArticleen_US

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